Free Fatty Acids and Sarcopenia Risk in Type 2 Diabetes: Insights From SHAP Analysis

Abstract

Sarcopenia is a prevalent and disabling complication of Type 2 diabetes mellitus (T2DM), which significantly elevates the risks of falls, fractures, institutionalization, and all‐cause mortality. Lipotoxicity mediated by circulating free fatty acids (FFA) is crucial in the pathogenesis of diabetes‐related sarcopenia, but the independent association and dose–response pattern between serum FFA levels and sarcopenia risk in T2DM patients remain poorly clarified.