It is found that A. cavernosa retains the full eukaryotic ancestral mevalonate pathway for terpene precursor biosynthesis, providing additional evidence for the ancestral origin of metazoan terpenoid biosynthesis and further the understanding of early metazoan adaptive evolution.
Highly diversified specialized metabolism enables plant communication with pollinators, herbivores, and protectors1–4. Its chemodiversity, under which evenness, richness and variation is summarized5–7, includes many compounds without known function1–4 and presents an evolutionary conundrum about how and what is selecte...
These findings systematically elucidate the biosynthesis of monoterpenoids in A. annua and provide key enzymatic elements for metabolic engineering and synthetic biology applications in monoterpenoid production.
Plants produce a great chemodiversity, which is the diversity of specialized metabolites (SMs). These SMs are produced in complex metabolic pathways and play an important role in inter-species interactions. There are numerous hypotheses about the evolutionary processes which brought about and maintain chemodiversity. S...
This study elucidates the adaptive mechanisms by which endophytic fungi remodel their metabolic networks to efficiently synthesize plant-derived terpenoids and provides novel strain resources and a theoretical basis for the sustainable manufacturing of terpenoid natural products using synthetic biology strategies.
Closely related plant species often exhibit striking diversity in their specialized metabolism, yet the genomic and evolutionary mechanisms driving this divergence are often elusive. The globally important cinnamon species Cinnamomum cassia and C. verum represent a classic example, producing leaf essential oils dominat...
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