Aug 2026· Diabetes, obesity and metabolism· Vol 28, pp. 9880 - 9896· 0 citations· 39 references
Medicine
Abstract
Endothelial dysfunction induced by elevated free fatty acids is a critical initiating event in diabetic macrovascular complications. While mitochondrial reactive oxygen species (mtROS) are key mediators of this lipotoxic injury, the specific contribution of mitochondrial Complex I dynamics and its associated redox regulation remains to be fully elucidated.
Aberrant activation of dynamin‐related protein 1 (Drp1) promotes excessive mitochondrial reactive oxygen species (mtROS) production; however, whether the Drp1‐mtROS pathway mediates the renoprotective effects of aerobic exercise remains unclear.
Hui-Qian Ren, Hao-Feng Sun, Zhe-Ying Ma et al.· Acta Physiologica· 0 citations
Nuclear factor erythroid 2-related factor 2 (NRF2) is a master regulator of antioxidant signaling. Xirouchaki et al. show that NRF2 activation in skeletal muscle regulates metabolic homeostasis and healthy aging. Complementary evolutionary adaptations enhancing NRF2 signaling in horses underscore its role in muscle fun...
Jaydeep Sharma, Mahima Kumari, Sam J. Mathew· Trends in endocrinology and...· 0 citations
Insulin resistance (IR) is a key pathological basis of metabolic diseases. Dityrosine (Dityr), a characteristic protein oxidation product commonly present in over-processed foods, can induce IR by disrupting metabolic homeostasis....
Jia Chen, Jing-Nan Zhu, Qin Jia et al.· Food & Function· 0 citations
This poster focuses on the part of the central nervous system that is affected by CHF and focuses on the part of the immune system that is affected by CHF.
Yang Ge· Journal of Alternative, Comp...· 0 citations
