Aug 2026· Infection and Immunity· Vol 94· 1 citation· 120 references
Medicine
Abstract
ABSTRACT The pathogenic yeast Cryptococcus neoformans causes life-threatening meningoencephalitis in individuals with compromised immune systems. The ability of the fungus to cause disease depends on key cell-surface features, such as a polysaccharide capsule that protects it from the mammalian immune system. However, the mechanisms by which C. neoformans traffics polysaccharide capsule, melanin, and other materials to the cell surface are poorly understood. In this study, we employed mutants lacking specific subunits of the adaptor protein complex 1 (AP-1) to investigate its role in the elaboration of virulence-related materials at the cell surface. Importantly, the mutants displayed multiple defects, including alterations in capsule size and cell morphology, and defects in melanin production and urease secretion. Together, these results support the key observation that the AP-1 complex is required for C. neoformans survival in phagocytic cells. Together, our findings provide insights into the endomembrane trafficking machinery required for fungal pathogenesis.
Burkholderia cenocepacia is a problematic pathogen that infects people with cystic fibrosis and can cause fatal "cepacia syndrome". B. cenocepacia infection is difficult to treat due to the high-level intrinsic resistance of the bacterium to antimicrobials and its ability to survive in macrophages. In this study, we un...
H. Shropshire, Xu Han, Zeng-Sheng Han et al.· Journal of Biological Chemis...· 0 citations
ABSTRACT Coxiella burnetii is an obligate intracellular bacterial pathogen that causes the zoonotic disease Q fever. Coxiella extensively subverts host vesicle traffic and replicates within lysosome-derived, spacious vacuoles by secreting a suite of effectors through the type IVB secretion system (T4BSS). This study in...
Hrithik Kumar, Amrita Bhattacharya, Sayanthana Benny et al.· Infection and Immunity· 0 citations
Enteroviruses are among the most common viral pathogens in humans, causing illnesses ranging from the common cold to severe and sometimes life-threatening diseases such as acute haemorrhagic conjunctivitis or poliomyelitis. To replicate efficiently within host cells, enteroviruses hijack several host factors, including...
Vladimira Horova, Michala Zgarbová, M. Klíma et al.· Antiviral Research· 0 citations
This study studied ORF55, a tail fiber protein from Pseudomonas phage phiPA1-3 that contains an SGNH hydrolase domain, and generated two highly stable tools: a potent enzyme to eradicate multidrug-resistant biofilms and a sensitive diagnostic probe for rapid pathogen detection.
Patients infected with mycobacteria, particularly Mycobacterium abscessus, frequently experience antibiotic treatment failure. Phage therapy, used under compassionate care, offers a promising alternative and has already demonstrated clinical efficacy. However, phage-bacteria interactions and their coevolution remain...
M. Illouz, Valentin Wasselin, Adrián Pál et al.· ACS Infectious Diseases· 0 citations
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