NRP1 silencing induces ROS-mediated cell cycle arrest and mitochondrial apoptosis in non-small cell lung cancer via upregulation of AGER

STT3 promotes cervical cancer proliferation and apoptosis via PI3K/AKT pathway

Highlights • Cervical carcinoma tissues exhibit elevated expression of STTA and STT3B, with this overexpression significantly correlated with poor patient prognosis.• Knockdown of STT3 markedly impedes the cell cycle in cervical carcinoma cells, inhibiting tumour proliferation while promoting apoptosis.• STT3 regulates...

Role of CircRNA_0005075 in gastric cancer immune evasion through regulation of lactate metabolic reprogramming and histone lactylation

circRNA_0005075 knockdown potentiates anti-PD-1 therapy in vivo, suggesting a therapeutic target for gastric cancer.

CNTN5 Promotes Invasion and Metastasis in Non‐Small Cell Lung Cancer by Regulating YAP1 Nuclear Translocation

Non‐small cell lung cancer (NSCLC) is a leading cause of cancer‐related death worldwide, largely owing to its high metastatic potential. Contactin‐5 (CNTN5), a glycosylphosphatidylinositol‐anchored membrane protein, has been implicated in tumor‐related processes; however, its role in NSCLC progression remains unclear....

Allicin activates ER stress-induced IRE1α-JNK pathway and apoptosis via caspase-3/9 in BT-549 cell line

Allicin acts as a pro-oxidant, regulating programmed cell death pathways in BT-549 cancer cells through ROS signaling, and the involvement of reactive oxygen species in regulating these signaling pathways is indicated.

EZH1/2 inhibition selectively targets SMARCA4/2 co-deficient lung cancer cells by suppressing stemness and proliferation

Highlights • SMARCA4/2 co-deficient lung cancer cells share transcriptomic features with SMARCA4-UT.• The EZH1/2 inhibitor HM97662 selectively suppresses growth in SMARCA4/2-deficient cells.• HM97662 induces apoptosis and attenuates stemness marker expression selectively.• Broad PRC2 target derepression, but selective...

Loss of 4E-BP1 Function Induces EMT and Promotes Cancer Cell Loss of 4E-BP1 Function Induces EMT and Promotes Cancer Cell Migration and Invasion via Cap-Dependent Translational Migration and Invasion via Cap-Dependent Translational Activation of Snail Activation of Snail