STT3 promotes cervical cancer proliferation and apoptosis via PI3K/AKT pathway

RSPO1–LGR4 axis drives cervical cancer progression via activation of the EGFR/Src/ERK/AKT signaling pathway

Highlights • RSPO1 is upregulated in cervical cancer.• RSPO1 promotes proliferation, migration, invasion, and tumorigenesis in vitro/vivo.• RSPO1 activates EGFR/Src/ERK/AKT axis via LGR4 in cervical cancer.• RSPO1-LGR4 stabilizes EGFR by blocking c-Cbl-mediated ubiquitination/degradation.

PCK1 promotes gastric cancer progression by activating the SRC1-JAK1-STAT3 signaling axis

Highlights • PCK1 is overexpressed in gastric cancer and promotes tumor growth and metastasis.• PCK1 activates the SRC1-JAK1-STAT3 cascade in gastric cancer cells.• The PCK1-SRC1-STAT3 pathway is a potential therapeutic target for gastric cancer.

MATR3 promotes proliferation and invasion of colon adenocarcinoma cells: bulk, single-cell transcriptomic analysis and experimental validation

Highlights • MATR3 is significantly upregulated in colorectal cancer tissues and is associated with poor prognosis in patients.• Knocking out MATR3 significantly inhibits the proliferation, migration, and invasion ability of colorectal cancer cells.• Animal experiments have confirmed that knocking out MATR3 can signifi...

NPM1 drives cancer cell migration and invasion by amplifying EGFR gene expression and its downstream signaling

Cancer-associated fibroblasts-derived CAV1 promotes epithelial-mesenchymal transition and stemness in bladder cancer through activation of the LIF/STAT3 signaling pathway

CAV1 is identified as a fibroblast-associated gene linked to stemness- and ferroptosis-related signatures and promoting bladder cancer progression by activating the LIF-STAT3 signaling axis.

CDS2 Drives Tumor Progression in Epithelial Ovarian Cancer via the PI3K/AKT Pathway

Epithelial ovarian cancer (EOC) frequently disseminates within the lipid‐rich peritoneal cavity, where tumor progression is accompanied by metabolic adaptations involving lipid utilization and mitochondrial function. Although these metabolic alterations are increasingly recognized as important features of EOC progressi...