TL;DR
It is suggested that JQR exerted therapeutic effects on AGA via the coordinated regulation of multiple components and targets through the Ras/Raf/MEK/ERK signaling pathway.
BACKGROUND Zaoshi Huatan Xiefei Formula (ZHXF) is a Chinese medicine prescription used in the treatment of severe pneumonia (SP). Although clinical studies have confirmed its efficacy in improving pneumonia, the specific bioactive components and their intricate regulatory pathwaysremain incompletely understood. PURPO...
Background Acute gouty arthritis (AGA) is an acute inflammatory disorder triggered by the deposition of monosodium urate crystals (MSU) in the joints, clinically characterized by severe pain and transient limitation of joint mobility. Without proper intervention, recurrent episodes can lead to irreversible joint deform...
CNZP exhibits significant therapeutic effects on RA, potentially by downregulating NOS1 expression and subsequently correcting the metabolic imbalance of L-arginine, and this preclinical study provides mechanistic evidence for the anti-RA effect of CNZP.
This study systematically elucidates the potential mechanisms underlying the antihypertensive effects of ZLJYD through multiple components, targets, and pathways, particularly immune regulation and gut microbiota remodeling and provides mechanistic insights into its potential therapeutic application.
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