Experimental results showed melatonin reduces SW480 viability with an IC₅₀ of 2.63 mM and lowers BUB1 and CCNA2 expression in different manners of concentration-dependency, while NCAPG remains unchanged, and selective repression of two NF-Y targets with sparing of a non-target is consistent with reduced NF-Y-dependent transcription.
These findings establish CAST as a tumor-specific suppressor in CRC and provide a generalizable framework for discovering therapeutic targets from unannotated isoforms.
RCBTB2 (RCC1 and BTB domain-containing protein 2), located at chromosome 13q14, is affected by deletion, amplification, expression change, or gene fusion across the cancers studied to date. The divergent directions of these alterations do not fit a tumor-suppressor model with a fixed direction of action. Here, genetic,...
Chuanhai Cai, Jianjun Du, Li-Ga Tu et al.· Frontiers in Oncology· 0 citations
Background Reversing the tumor phenotype is a long-standing challenge in cancer biology. Although GRNs comprise thousands of genes, normal and tumor tissues occupy distinct, low-dimensional attractors in expression space, raising the possibility that targeting a few key genes could induce widespread transcriptional cha...
Gabriel Gil, Rolando Pérez, Augusto Gonzalez· Frontiers in Systems Biology· 0 citations
It is demonstrated for the first time that LOY is significantly enriched in advanced-stage disease and the aggressive basal molecular subtype, establishing LOY as a causal genetic driver of PDAC progression, acting through epigenetic remodeling to promote EMT, basal subtype identity, metastasis, and therapy resistance.
M. Dorsch, Felix E. G. Beaudry, A. Baginska et al.· Cancer Research· 0 citations
Introduction Despite advances in colorectal cancer (CRC) treatment, the chromosomal instability (CIN)-positive subgroup remains refractory to conventional therapies and immunotherapy. C2orf76, a poorly characterized gene identified as a CIN-linked candidate in CRC through bioinformatic analyses, has been associated wit...
Li Zhang, Zhu Song, Pin-Jie Zhang et al.· Frontiers in Oncology· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
