An integrative evaluation of in vitro anti-inflammatory potential, network pharmacology and molecular docking of Girardinia diversifolia (Urticaceae) relevant to rheumatoid arthritis

In Vitro Anti-Inflammatory Evaluation, Gene Expression, HR-LC–MS Profiling, and in silico Molecular Docking of Active Fraction from Rauvolfia densiflora Benth. ex Hook.f. (Apocynaceae)

Chemical Profiling and Therapeutic Investigations on Grewia gamblei J.R. Drumm for Potential Antioxidant and Anti-inflammatory Applications: An in vitro and in silico Approach

The remarkable antioxidant and anti-inflammatory properties of the methanolic leaf extract, and important pharmacokinetic and molecular interactions of the phytocompounds, support the findings of Grewia gamblei as a natural anti-inflammatory potential.

Metabolic profiling and multitarget in silico docking reveal the anti inflammatory and anti arthritic potential of Ricinus communis L formulations

The phytochemical composition of R. communis methanolic oil and cream formulations is investigated and their structural stabilization effects on proteins alongside in silico binding predictions against pro-inflammatory targets are evaluated to provide a structural and biochemical baseline.

Integrated UHPLC-MS/MS Metabolomics, Network Pharmacology, Molecular Docking, and Experimental Validation Reveal the Anti-Inflammatory Mechanisms of Pyrus pyrifolia Peel Extract

Pyrus pyrifolia (Burm. f.) Nakai has long been utilized in traditional East Asian medicine to treat respiratory disorders, fever, cough, and inflammatory conditions. This study aimed to evaluate the antioxidative and anti-inflammatory effects of P. pyrifolia. UHPLC-MS/MS analysis revealed that P. pyrifolia contained 22...

Elucidating the potential anti-liver cancer mechanisms of the medicinal food Rosa roxburghii Tratt. by integrating HPLC-Q Exactive MS/MS, network pharmacology, and in vitro validation.

This study integrated HPLC-Q Exactive Plus MS/MS analysis, network pharmacology, molecular docking, and in vitro assays to investigate the anti-liver cancer mechanisms of flavonoid components from Rosa roxburghii Tratt. (RRT) ethanol extract. A total of 52 flavonoids were identified, including 15 active compounds assoc...

Integrated network pharmacology and metabolomics reveal the mechanisms of Compound Nanxing Zhitong Plaster in anti-rheumatoid arthritis.

CNZP exhibits significant therapeutic effects on RA, potentially by downregulating NOS1 expression and subsequently correcting the metabolic imbalance of L-arginine, and this preclinical study provides mechanistic evidence for the anti-RA effect of CNZP.