Gene expression studies revealed that these nanocarriers promote cell death through oxidative stress-mediated pathways, with excessive ROS generation consistent with ferroptosis associated mechanism of cell death, thereby linking ferroptosis- associated responses with inhibition of tumor progression.
Abstract Mitoxantrone (MTX) is limited by cardiotoxicity and MDR. At the same time, graphene oxide (GO) and nano-graphene oxide (NGO) offer ultrahigh surface area, strong π–π interactions with aromatic drugs, and versatile surface chemistry, making them superior to many conventional nanocarriers for high-capacity, stim...
Zahra Talebi Haftadori, Leila Mahdavian, Z. Mirjafary et al.· International Journal of Nan...· 0 citations
Triple-negative breast cancer remains a formidable clinical challenge owing to its immunosuppressive microenvironment and inherently low immunogenicity.
To address this, we developed a multifunctional Pickering emulsion (Fe-PDA-PE-R837) stabilized by iron-doped polydopamine (Fe-PDA) nanoparticles, which func...
Ling-Yu Xu, Peng Zhang, Min-Jing Yu et al.· Frontiers in Pharmacology· 0 citations
Background Malignant melanoma is a highly aggressive skin cancer. Dacarbazine (DTIC) chemotherapy, while historically used, is limited by poor solubility, short half-life, and systemic toxicity. Fe3O4 nanoparticles have been explored as drug delivery vectors with potential for photothermal conversion and Fenton-like ca...
Hao Ding, Dan-Li Li, Zi-Yi Zhou et al.· International Journal of Nan...· 0 citations
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