This study characterizes this dual-lineage phenotype in hepatocellular carcinoma and investigates its association with SPINT2, and identifies SPINT2 as a candidate molecule associated with these malignant phenotypes.
Abstract
Simple Summary Liver cancer displays substantial tumor-cell heterogeneity, including tumor cells that simultaneously express hepatocytic and cholangiocytic markers. This study characterizes this dual-lineage phenotype in hepatocellular carcinoma and investigates its association with SPINT2. By integrating patient tissue profiling, single-cell analyses, and functional experiments, we show that this phenotype is associated with adverse clinical outcomes and aggressive tumor features. SPINT2 is further identified as a candidate molecule associated with these malignant phenotypes. These findings provide insight into HCC cellular plasticity and the biological heterogeneity of dual-lineage tumor states.
Hepatoblastoma (HB) is the most common primary pediatric liver cancer. Among childhood tumors, it has one of the highest mortality rates with 20% cases resulting in death or liver transplantation. Identifying high-risk tumors has been challenged by tumor heterogeneity. Current clinical high-risk stratification re...
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High-resolution mapping of 52,384 cells uncovers hierarchical intra-tumor heterogeneity in HCC and TMEM176B is identified as the link between tumor malignancy hierarchy and immune remodeling.
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Serine Protease Inhibitor Kunitz type-2 (SPINT2) has been reported to play a role in the progression of various tumor types. This inhibitor is generally described as a tumor suppressor that affects migration and invasion. However, a few recent studies have reported the opposite, suggesting an oncogenic role for
SP...
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