Review

Pan-genomics and multi-omics for deciphering genetic variation and accelerating genetic improvement in ruminant livestock

Diba Dedacha Jilo B. Abebe Waheed Ullah Jun-Tao Guo Jian-Fang Wang Hao-Bin Ma Yi-Heng Liu Gong Cheng Huan-Huan Cui L. Zan

Sep 2026 · Functional & Integrative Genomics · Vol 26 · 0 citations · 89 references

Medicine

TL;DR

Current dairy-cattle evidence indicates that pangenome-derived structural variants can substantially improve variant discovery and functional interpretation while yielding only marginal average gains in routine genomic prediction, favoring targeted augmentation rather than wholesale replacement of established SNP-based evaluations.

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