The Single Amino Acid Substitution in WcaJ(Ser332Leu) Promotes Hypervirulent Klebsiella Pneumoniae Resistant to Bacteriophage and Virulence Attenuated.
Jul 2026· Probiotics and Antimicrobial Proteins· 0 citations· 34 references
Medicine
TL;DR
This investigation investigated the phage-host interaction between phage vB_LZ2044 and hvKP strain NTUH-K2044, yielding a phage-resistant mutant PR_K2044, providing critical insights for optimizing phage-based therapeutic strategies against multidrug-resistant pathogens.
Klebsiella variicola
(KV) infections are being increasingly reported across diverse geographic regions and linked to high mortality. KV displays substantial geographical heterogeneity in antimicrobial resistance profiles, virulence phenotypes, and genetic backgrounds; genetic variants further promote its adaptabilit...
Yu-Ting Kang, Ze-Zhou Zhang, Si-Yu Ma et al.· Frontiers in Microbiology· 0 citations
Klebsiella pneumoniae phage KP Ø1 is a novel, obligately lytic Slopekvirus whose genomic architecture, stability profile, and absence of lysogeny-associated, virulence, and antimicrobial resistance genes collectively support its candidacy for further preclinical evaluation as a phage therapy agent against uropathogenic...
Reham Fadl, Ghada Ismail, A. Elshafei et al.· Scientific Reports· 0 citations
Background The rapid global spread of hypervirulence in Enterobacteriaceae, particularly in carbapenem-resistant Klebsiella pneumoniae, poses a significant public health threat. However, the key genetic vehicles and mechanisms driving horizontal transfer of hypervirulence-associated genes (iucA, iroB, rmpA, rmpA2, and...
Shuaihua Fan, Lijun Wang, Chao Liu et al.· PLoS Pathogens· 0 citations
Klebsiella pneumoniae
frequently causes hospital-acquired and community-acquired infections, posing a serious threat to human health. Lytic phages can rapidly propagate within host bacterial cells and release progeny phages, ultimately inducing the death of the host bacteria.
K. pneumoniae
depolymerases are...
Jie Wang, Lu Zhang, Shi-Yan Jiao et al.· Virology Journal· 0 citations
Carbapenem-resistant Klebsiella pneumoniae (CRKP) has become a substantial public health threat worldwide. This trend is undoubtedly exacerbated by biofilm formation, which is closely related to bacterial virulence. Small RNAs (sRNAs) are post-transcriptional regulators of many biological processes in bacteria, includi...
Na Du, Min Yang, Yong-Shi Zhao et al.· Microorganisms· 0 citations
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