2026· Advances in Pharmacology· Vol 106, pp.
253-281
· 0 citations
Medicine
TL;DR
This chapter highlights examples of cell tracking and labeling strategies for engineered T cell therapies that can noninvasively track labeled cells on a whole-body level and enable long-term monitoring of adoptively transferred cells in a manner compatible with the proliferation and persistence of therapeutic cells.
In vivo CAR-T is poised to broaden the reach of cellular immunotherapy, provided that its development is guided by rigorous pharmacology, chemistry, manufacturing and controls, and long-term molecular safety surveillance.
Wan-Ting Wang, Yujia Cai, Xuanming Yang et al.· Immunity & Inflammation· 0 citations
Key challenges related to the biodistribution, activation, and persistence of modified T cells are highlighted, with an emphasis on the potential of these strategies for treating not only blood cancers but also solid tumors, autoimmune diseases, and beyond.
Jens B. Simonsen, Viktor T. Lemgart, J. Kulkarni et al.· Advanced Drug Delivery Revie...· 1 citation
Preclinical studies are described demonstrating that UB-VV400 generates anti-CD22 CAR T cells that kill CD22-expressing B cells and tumor cells in vitro and in vivo, and that engagement of RACR results in the selective expansion and enrichment of CAR T cells in vivo leading to complete tumor clearance and B cell deplet...
Travis J. Friesen, Alyssa Sheih, Nikole Perdue et al.· Molecular Therapy· 0 citations
This review synthesizes recent advances in molecular engineering strategies that enhance CAR-T cell function beyond conventional receptor design and discusses how receptor engineering, genome editing, transcriptional and epigenetic regulation, metabolic reprogramming, synthetic gene circuits, and safety-control platfor...
Hany E. Marei, G. Pozzoli, S. Caratelli et al.· Stem cell research & therape...· 0 citations
This review summarizes recent advances in molecular imaging techniques for monitoring the in vivo fate of CAR-T cells, covering their dynamic distribution, tumor recognition, and real-time functional activity and proposes an interdisciplinary integration of these approaches.
Hong-Yi Wang, Yan Yan, Yue-Ping Li et al.· Frontiers in Immunology· 0 citations
