DDX41 mutations establish a separate entity in acute myeloid leukemia with distinct survival outcomes

Abstract

Recurrent germline variants in DDX41 represent the most common inherited predisposition to adult myeloid neoplasms, occurring in approximately 3% – 5% of patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). 1,2 Clinically, patients with DDX41 ‐ mutated AML are typically older at diagnosis, predominantly male