Nilotinib Tartrate Encapsulated Polycaprolactone Polymeric Nanoparticle Fabricated With Lactoferrin for the Treatment of Colorectal Cancer: In-Silico and In-Vitro Investigation
Preliminary preclinical data supporting NiloT-PCL-Lf-NPs as a viable targeted nanotherapeutic platform for colorectal cancer is provided, warranting additional in vivo validation.
The developed chitosan-coated Eudragit® S100 nanoparticle system represents a promising platform for sustained, colon-targeted oral delivery of HSP and other poorly bioavailable bioactive compounds.
Andrographolide (AG) has been reported for its anticancer activity. However, it is classified as a class IV in the biopharmaceutics classification system (BCS). Therefore, AG possesses low bioavailability due to its low solubility and permeability. In this study, hyaluronic acid-coated chitosan nanoparticles (Hyalo-CS-...
Sohaila A. Shoala, H. Abbas, H. Elbedaiwy et al.· European journal of pharmace...· 0 citations
The developed nanoliposomal system offers significant clinical advantages including potential for enhanced tumor targeting, reduced dosing frequency, and minimized systemic toxicity, pending in vivo validation, and improved therapeutic outcomes.
Mayur R. Nikam, D. Sonawane, A. Pawar· BioNanoScience· 0 citations
A magnetically responsive, biocompatible Fe3O4@SiO2 nanoparticle functionalized with a bromocholine-based ionic liquid that combines tunable drug release, biointerfacial compatibility, and rapid healing efficacy, making it a promising candidate for advanced wound therapy.
This study explored the potential of gold nanorods (AuNRs) functionalized with polyethylene glycol (PEG) and loaded with non-steroidal anti-inflammatory drugs (NSAIDs) fenamic acid (fenH) or its bromo-derivative (4′BrfenH) for targeted drug delivery and preclinical cancer research, given their pH-dependent drug-release...