Zeylenone-mediated inhibition of TIMP-1-induced Bax/Bcl-2/Cle-caspase-3 expression and apoptosis via FAK-PI3K/AKT pathway regulation in thyroid cancer cells: in vitro and in silico study

Robinin modulates TIMP-1/FAK/PI3K/Akt/mTOR-related signaling and induces oxidative stress-associated apoptotic responses in KB cells: in vitro and in silico evidence

ROS-Activated SHP-1 Signaling Underlies Artesunate-Mediated Inhibition of EMT and STAT3-Driven Prostate Cancer Progression.

Collectively, ART suppresses PC growth, survival, migration, and EMT by targeting the STAT3 and ROS/SHP-1 signaling pathways, supporting its potential as a therapeutic candidate for PC.

Sophocarpine Inhibits Proliferation and Triggers Apoptosis in Breast Cancer Cells by Modulating the miR-21/PTEN/AKT and ERK1/2 Signaling Networks

Findings identify SC as a potential structural scaffold exhibiting preliminary anti-tumor activity against breast cancer cells, at least in part, through modulating miR-21 and inhibition of the AKT/mTOR/ERK1/2 survival network.

Bullatine A Attenuates Proliferation in Breast Cancer Cells by Apoptosis via PI3K/AKT/mTOR Signaling Pathway in Vitro and in Silico Analysis and Pharmacological Analysis

It was revealed that BLA could reduce MCF-7 cell viability, adhesion, and migration while elevating intracellular ROS, autophagy, and apoptosis in an amount-dependent way and that BLA may be a natural anti-cancer agent to prevent BC metastasis.

Allicin activates ER stress-induced IRE1α-JNK pathway and apoptosis via caspase-3/9 in BT-549 cell line

Allicin acts as a pro-oxidant, regulating programmed cell death pathways in BT-549 cancer cells through ROS signaling, and the involvement of reactive oxygen species in regulating these signaling pathways is indicated.

PD16, a steroidal saponin, induces apoptosis in colorectal cancer via inhibiting the AKT/GSK3β signaling pathway.

Findings provide the first evidence that PD16 exerts pro-apoptotic effects in CRC cells through the AKT/GSK3β pathway inhibition, thereby confirming it as a valuable novel therapeutic candidate for CRC.