Subclinical inflammation and early pathogenesis of rheumatic diseases: mechanistic insights relevant to primary care.

Pathogenesis of rheumatoid arthritis: one year in review 2026.

This work has shown that due to recent findings obtained at cellular and molecular levels, it has been possible to better define the interactions between the innate and adaptive immune systems and to better explain how RA-specific antibodies can exert a regulatory effect on the innate immune system.

World Journal of Clinical Pediatrics

This review examines the clinical spectrum of rheumatological manifestations associated with IEIs, encompassing arthritis, cytopenias, vasculitis, macrophage activation syndrome, systemic lupus erythematosus, inflammatory bowel disease phenotypes, polyautoimmunity, and autoimmune lung disease.

Mechanisms underlying rheumatic heart disease immune-mediated pathogenesis: T-cell responses, cytokine networks, and immune dysregulation as drivers of valvular injury.

Acute rheumatic fever is an immune-mediated sequela of Streptococcus pyogenes (group A Streptococcus) infection, presenting with fever, arthritis, chorea, rash, and, crucially, carditis. Without effective secondary prophylaxis and care, acute rheumatic fever can progress to chronic rheumatic heart disease, a leading ye...

Regulated cell death in autoimmune diseases: molecular mechanisms and therapeutic opportunities

Improved understanding of the integrated landscape of the RCD network may facilitate the discovery of novel biomarkers and support the development of innovative therapies to restore immune tolerance and control chronic inflammatory damage in autoimmune diseases.

Resolution Failure in Multiple Sclerosis: Linking Lipid Mediators to Neuroinflammation and Disease Progression.

Haematological Consequences of Systemic Inflammation: A Critical Narrative Review of Pathophysiology, Clinical Manifestations, Biomarkers and Therapeutic Implications

Inflammation is inseparable from blood-cell biology: circulating cells detect inflammatory cues, bone-marrow progenitors alter lineage output, erythroid iron supply is actively restricted, and haemostatic pathways can be recruited as components of host defence. Yet the expression “haematological inflammation” is used i...