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Comprehensive Assessment and Benchmark of Deep Generative Models for Proteolysis TArgeting Chimera (PROTAC) Design

Jieyu Jin Tingjun Hou Huanxiang Liu X. Yao
May 2026 · Journal of Chemical Information and Modeling · Vol 66 9, pp. 5301-5314 · 0 citations
Computer Science Medicine

TL;DR

This work aims to discuss the features and the generative performance of different types of molecular generative models for the PROTAC design task and help researchers to better apply these models in practical cases.

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