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Open access

Mutations in SARS-CoV-2 Nsp1 are critical determinants of viral pathogenicity in mice

Nathaniel Jackson Fu-Chun Zhou Anastasija Cupic Tolga Cagatay Haiping Hao Vinay Shivanna Ruby A. Escobedo Kevin Chiem C. Ye Lisa Miorin B. Fontoura Adolfo García-Sastre A. Bukreyev Luis Martínez-Sobrido
Aug 2026 · bioRxiv · 0 citations · 3 references
Biology

TL;DR

The reduced pathogenicity of rSARS-CoV-2 Nsp1 mutants highlights the potential for targeting Nsp1 for rational design of viral inhibitors and development of live-attenuated vaccine strategies as effective prophylactic and therapeutic treatments to combat SARS-CoV-2 and possibly other CoV infections.

DOI Semantic Scholar
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