Spatiotemporal transcriptomics of human cardiovascular progenitors in pig hearts identifies Midkine as a positive regulator of neovascularization

Swarnaseetha Adusumalli Kye Siong Leong Samantha Lim Vincent Ren L. Chong Clarissa L. L. Tan R. Tham Min-En Cheng Lei Ye Yibin Wang Enrico Petretto Lynn Yap

Jul 2026 · Nature Cardiovascular Research · Vol 5, pp. 744 - 762 · 0 citations · 67 references

Medicine

TL;DR

It is shown that the engrafted cardiovascular progenitors progressively upregulated genes associated with cardiac maturation, oxidative metabolism, calcium handling and fibrosis resolution, and MDK is identified as a tractable target for therapeutic angiogenesis in ischemic heart disease.

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