Skip to content
Log in
Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
#protein folding

Integrated genomic, immunoinformatic and experimental evaluation of conserved pneumococcal surface proteins for serotype-independent vaccine development.

Sangeetha Gopalakrishnan Premkumar Jayapal P. Selvamani A. Pavithra S. M. Ramakrishnan K. L. Ravikumar K. Parthasarathy James John
Oct 2026 · Journal of Applied Genetics · 0 citations · 35 references
Medicine

TL;DR

PsaA is the most promising serotype-independent vaccine candidate, while other AdcA, AmiA, and Lmb represent potential antigens for multicomponent formulations.

DOI PubMed Semantic Scholar
View source

Similar papers

Open access Oct 2026

Integrated Pangenome, Immunoinformatics, and Structural Biology Approaches for the Design of a Multi-Epitope Vaccine Against Streptococcus Anginosus

Background: Streptococcus anginosus is an opportunistic bacterial pathogen associated with clinically significant infections, including brain abscesses, bacteremia, empyema, and infective endocarditis. The absence of an approved vaccine against this organism warrants investigation of potential preventive candidates. Ac...

Reem A. Alromaihi · 0 citations
Open access Sep 2026

In Silico Prediction and Structural Mapping of Linear B-Cell Epitopes in Andes Virus Glycoprotein as Potential Vaccine Candidates

Andes virus (ANDV), a pathogenic orthohantavirus associated with hantavirus cardiopulmonary syndrome, remains a public health concern because of its severe clinical outcomes and the absence of broadly approved vaccines for human use. The viral glycoprotein is a relevant antigenic target because of its surface localizat...

A. R. Siregar, H. K. Nariswari, M. R. Afnani et al. · 0 citations
Open access Oct 2026

An OmpX mRNA-LNP vaccine induces protective humoral and cellular immunity against Klebsiella pneumoniae in a C57BL/6 mouse model

Klebsiella pneumoniae (KP) poses a significant threat to global public health, and effective preventive measures are urgently needed. The widespread antibiotic resistance of KP underscores the critical need for vaccine-based strategies. Although numerous vaccine candidates against KP have been investigated, none has ye...

Yun-Wang Zhao, Hong-Xian Cheng, Shi-Yi Zhou et al. · 0 citations
Open access Oct 2026

IDENTIFYING KLEBSIELLA PNEUMONIAE VACCINE CANDIDATES THROUGH PAN-GENOMICS

The rise of multidrug-resistant Klebsiella pneumoniae strains and the lack of licensed vaccines highlight the urgent need for effective immunization strategies. The pan-genome analysis was performed to find out the core proteins of K. pneumoniae using reverse vaccinology approaches. Selected core proteins based on subc...

Asma Bibi, Marriam Bakhtiar, S. A. Jan et al. · 0 citations
Open access Sep 2026

Design and Evaluation of a Multi-Epitope Vaccine Targeting Conserved Envelope and NS5 Proteins of Usutu Virus Using Immunoinformatics

An integrated reverse vaccinology strategy is used to identify conserved immunogenic regions from the Envelope protein and NS5 protein, and construct a multi-epitope vaccine for Usutu virus, predicting enhanced humoral and cellular immune-response patterns following repeated antigen administration.

Reem A. Alromaihi, H. Alharbi, S. Almerdasi et al. · 0 citations

Related blog posts

Google DeepMind Blog Sep 30, 2026

Introducing SynthID Bio

Proof of concept for watermarking AI-generated proteins while preserving biological function.

MIT News · Artificial Intelligence Aug 27, 2026

Looking beyond natural sequences

A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.