A comprehensive DNA methylome BodyMap is constructed across 12 organs or tissues from mice exposed to long-duration spaceflight across three time points, elucidating the tissue specificity of epigenetic changes and essential for developing biomarkers and countermeasures to safeguard astronaut health during extended missions.
Intrinsic high aerobic capacity in aged skeletal muscle is associated with hypermethylation-enriched methylome remodeling, feature-dependent functional enrichment, distinct transcriptional signatures, and oxidative-metabolic protein differences.
Lei Zhou, S. Mozaffaritabar, F. Torma et al.· Journal of Sport and Health...· 0 citations
The results provide a high-resolution atlas of TE regulation under IF and demonstrate that TEs are integral components of tissue-specific transcriptional networks reshaped by fasting, offering new insights into how dietary interventions influence gene regulatory systems.
The findings suggest that multigenerational metabolic challenge can constrain genetic variability and induce genome instability, potentially mediated by transposable element activity rather than widespread changes in DNA methylation.
Violeta de Anca Prado, F. Pértille, Dennis Andersson et al.· bioRxiv· 0 citations
The genome-wide methylome and transcriptome of clinically healthy beagle dogs representing three distinct age groups showed partially overlapping but distinct hallmark associations, suggesting links to different age-related biological processes.
Dayeon Kang, Eun-yeong Bok, Chae-Yeon Hong et al.· GeroScience· 0 citations
As the first systematic atlas of the bat whole-brain proteome across a 24-hour cycle, this study uncovers molecular strategies maintaining brain homeostasis providing a foundation for understanding diurnal physiological adaptation, flight energy regulation, and circadian output pathways.
Tian-Hui Wang, Hui Wang, Xin Li et al.· Journal of Proteome Research· 0 citations
Analysis of peripheral blood mononuclear cell RNA-sequencing data from three Axiom-3 astronauts provided hypothesis-generating evidence supporting further evaluation of PIN1-associated transcriptional responses in larger astronaut cohorts using protein-level, functional, and cell-type-resolved analyses.
Cihan Taştan, Z. Uzun, Ceren Yıldırım et al.· Havacılık ve Uzay Çalışmalar...· 0 citations
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