The L. major virulence factor lipophosphoglycan defends against pore-forming toxins made by bacterial competitors, while the GP63 metalloproteinase activates pro-aerolysin like furin to protect L. major from aerolysin cytotoxicity.
ABSTRACT The pathogenic yeast Cryptococcus neoformans causes life-threatening meningoencephalitis in individuals with compromised immune systems. The ability of the fungus to cause disease depends on key cell-surface features, such as a polysaccharide capsule that protects it from the mammalian immune system. However,...
Eddy Sánchez-León, Kabir Bhalla, Victoria French et al.· Infection and Immunity· 1 citation
It is demonstrated that deficiencies in the AP-1 complex impair C. neoformans virulence, reveal distinct roles for individual subunits, and identify the complex as a potential target for therapeutic intervention in cryptococcosis.
Kabir Bhalla, Eddy Sánchez-León, Yu-Hsuan Huang et al.· Infection and Immunity· 0 citations
TpeX is identified as a bactericidal, colicin-like pore-forming T6SS effector whose membrane activity is controlled by a cognate immunity protein, thereby expanding the repertoire of membrane-targeting weapons used by P. aeruginosa in interbacterial competition.
Chantal Soscia, Sébastien Reig, D. Lefebvre et al.· bioRxiv· 0 citations
This study provides a comprehensive NMR and mutational analysis to characterise the mechanism of action of a miniaturised depolymerase, here mKP34gp57, targeting the clinically relevant K63 CPS, and shows by NMR that mKP34gp57 hydrolyses CPS with high efficiency through an endoglycosidase-retaining mechanism.
Ferran Nieto-Fabregat, Mario Privitera, Angela Marseglia et al.· International Journal of Bio...· 1 citation
Unexpectedly, cytosolic extracts of both WT- and α”SLO-infected macrophages contained all histone proteins, suggesting that nucleosomal complexes are released into the cytosol during GAS infection.
Cheryl Y. M. Okumura, A. Quezada, Kevin Lord et al.· Journal of Immunology· 0 citations
Innate immune cells sense pathogenic bacteria like Legionella pneumophila through patterns such as the protein flagellin, a critical component of the bacterial motility apparatus. Recognition of cytosolic flagellin in mouse immune cells is well understood and mediated by the receptors, neuronal apoptosis inhibitory pro...
Gaopeng Li, Kenyatta Doumanas, Xiao Liu et al.· bioRxiv· 0 citations
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