Skip to content
Log in
Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

TIF1γ regulates stability of regulatory T cells during inflammation

Eugenio Contreras-Castillo Jesús Daniel Zambrano-Romero H. N. Núñez-Martínez M. C. Marcial-Medina Javier Orozco-Cordoba D. Ríos-Ramírez Ofelia Muñoz-Paleta Diego Pérez-Vázquez Andrés Felipe Sáenz-Cabezas María Guadalupe García-Patiño J. L. Ramos-Balderas Gustavo Tapia-Urzúa Luis Tenorio-Hernández G. Guerrero Nallely Cano-Domínguez Diego Delgado-Zaldívar A. Candelario-Martínez Isaac Martínez-Racine Ileana Licona-Limón I. Madera-Salcedo F. Rosetti J. Crispín L. G. Noriega Porfirio Nava Araceli Pérez-López J. Maravillas-Montero Félix Recillas-Targa V. Valdés Marina Macías-Silva M. Robles-Flores Mayra Furlan-Magaril V. Kaartinen J. Henao-Mejía R. Flavell P. Licona-Limón
Aug 2026 · Nature Immunology · Vol 27, pp. 1887 - 1898 · 1 citation · 74 references
Medicine

TL;DR

It is shown that TIF1γ-deficient Treg cells lose Foxp3 expression and acquire effector phenotypes in a cell-intrinsic manner upon inflammatory challenge, and TIF1γ is identified as a critical regulator of Treg cell stability that restrains β-catenin–TCF7 signaling.

DOI PubMed Semantic Scholar
View source

Similar papers

Open access Aug 2026

H3.3 chaperone Hira primes the effector program and function of regulatory T cells

It is shown that the histone variant H3.3 is enriched in tissue Tregs compared to splenic Tregs and its chaperone Hira is a critical regulator of Treg effector program, revealing a previously unreported epigenetic mechanism critical for Treg effector differentiation and function.

Xiang-Xiang Cao, Meng-Jie Lv, Zhi-Han Lv et al. · 0 citations
Open access Sep 2026

Deletion of a distal IRF4 element prevents inflammation-induced reprogramming of human regulatory T cell fate

Regulatory T (Treg) cells in mice can lose lineage identity and acquire proinflammatory functions, but whether human Treg cells are similarly susceptible to cytokine-driven destabilization remains unclear. Here we established an in vitro model of human Treg cell destabilization defined by silencing of the lineage-speci...

Patrick Ho, Alexander Vu, Joey C. Leung et al. · 1 citation
Open access Jul 2026

KLF2 regulates CD8 T cell differentiation and migration in infection and cancer 2254075

KLF2 is identified as a hub transcription factor in the gene regulatory network of effector-like CAR T cells and demonstrated as a central regulator of the effector fate and migration of CD8 T cells.

Tuo-Qi Wu, Ziang Zhu, Ying Luo et al. · 0 citations
Jul 2026

MAP4K2 promotes regulatory T cell differentiation and attenuates T cell immunity 2256886

MAP4K family kinases are key kinases for T-cell-mediated immune responses; however, in vivo roles of MAP4K2 in immune regulation remain unclear. We used T-cell-specific MAP4K2 conditional knockout (T-MAP4K2 cKO) mice, single-cell RNA sequencing (scRNA-seq), and mass spectrometry analysis to study the role...

T. Tan, H. Chuang · 0 citations

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.