Aug 2026· 3 Biotech· Vol 16· 0 citations· 217 references
Medicine
TL;DR
This review highlights the pivotal role of mitochondrial dysfunction in MS progression and examines novel therapeutic strategies, with a specific focus on modulating autophagy to restore mitochondrial homeostasis.
Multiple sclerosis (MS) has conventionally been considered a prototypical autoimmune disorder. While modern immunotherapies effectively control relapsing conditions, they fail to avert progressive neuroinflammation, neurodegeneration, and remyelination failure. This review offers an evidence-based recontextualization....
Ghada A. Badawi, Rehab M. El-Sayed, Mohamed N. Fawzy· InflammoPharmacology· 0 citations
Targeting upstream mechanisms of mitochondrial impairment may provide a unifying strategy for understanding ALS pathogenesis and developing effective therapies.
Hiroshi Mitsumoto, H. Blasco, P. Corcia et al.· Biomolecules· 0 citations
Multiple Sclerosis (MS) is a chronic immune-mediated neurodegenerative disorder of the Central Nervous System (CNS) that affects more than 2.8 million people worldwide. It is recognized as one of the leading causes of non-traumatic neurological disability among young adults. It is an inflammatory demyelination disease...
K. Ravi, K. Arora· Current Neurovascular Resear...· 0 citations
A deeper understanding of cross-talk among metabolic, immune, vascular, vascular, and microbial systems may enable earlier intervention and more effective strategies to mitigate the neurological burden of diabetes.
Md Mahmudul Hoque, Shamima Akter, Jawad Ul Karim Mahir et al.· Current Diabetes Reviews· 5 citations
Novel insights are provided into the dynamics of the CNS lipidome during neuroinflammation and suggest that myelin lipid alterations could contribute to MS progression through mechanisms independent of neuroinflammation.
Michael Rodriguez, S. Bach, Krista A. Berlin et al.· Journal of Immunology· 0 citations
A better understanding of the GM-miRNA axis may facilitate the development of novel biomarkers and personalized therapeutic strategies, ultimately shifting MS management from symptomatic treatment toward precision, disease-modifying interventions.
Farzaneh Rafie Sedaghat, A. Hasani, V. Poortahmasebi et al.· Folia Microbiologica (Prague...· 0 citations
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