Investigating the effects of nicotinamide mononucleotide administration on testicular apoptosis, and mitochondrial function in doxorubicin-treated rats
Ramelteon mitigated acute cisplatin-induced testicular damage in rats by attenuating deterioration in sperm parameters and steroidogenesis-related changes, resulting in reduced pathological tissue damage in the testes and attenuation of deterioration in sperm parameters and testosterone levels.
Shun Kawamura, Koji Chiba, K. Tsubotani et al.· In Vivo· 0 citations
Centella asiatica demonstrates significant potential in mitigating DOX-induced oxidative damage, attenuating testicular injury and preserving the functional integrity of the male reproductive system.
F. Bedir, Z. Suleyman, H. Kocaturk et al.· International Journal of Mol...· 0 citations
Objective: Cisplatin is a well-known anticancer drug whose use has been limited due to a variety of side effects. Evidence has confirmed that cisplatin consumption is associated with cardiac toxicity. Unfortunately, no drug has yet been found to treat cardiac toxicity or reduce the side effects caused by cisplatin. How...
Hoori Heidari Kahkesh, Negin Amini, Mohammad Badavi et al.· Avicenna Journal of Phytomed...· 0 citations
Background and Objectives: The cellular antioxidant defense system is disrupted, which results in hepatotoxicity. When the antioxidant defence system is weakened, hepatocyte oxidative damage results from an increase in reactive oxygen radicals. The chemotherapeutic and immunosuppressive drug methotrexate (MTX) is often...
Omar W. Maher· Journal of Neonatal Surgery· 0 citations
Study results indicate that rufigallol may protect against cisplatin-induced nephrotoxicity; however, additional research is needed to confirm its effectiveness in humans.
Ameeduzzafar Zafar, O. Alsaidan, Mohammad Khalid et al.· Naunyn-Schmiedeberg's Archiv...· 0 citations
It is demonstrated that AT1R inhibition using Losartan successfully mitigates MTX-induced testicular damage by addressing this upstream mechanistic pathway and Losartan has been identified as a viable treatment strategy for preserving male reproductive function following cytotoxic therapy.
Somayeh Mohammadi Panah, M. Khezri, Hojat Ghasemnejad-Berenji et al.· Immunopharmacology and immun...· 0 citations
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