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Open access Aug 2026

Ramelteon Mitigates Cisplatin-induced Testicular Dysfunction in Rats

Ramelteon mitigated acute cisplatin-induced testicular damage in rats by attenuating deterioration in sperm parameters and steroidogenesis-related changes, resulting in reduced pathological tissue damage in the testes and attenuation of deterioration in sperm parameters and testosterone levels.

Shun Kawamura, Koji Chiba, K. Tsubotani et al. · 0 citations
2026

Hesperidin attenuates cisplatin-induced cardiotoxicity in rats through regulating autophagy

Objective: Cisplatin is a well-known anticancer drug whose use has been limited due to a variety of side effects. Evidence has confirmed that cisplatin consumption is associated with cardiac toxicity. Unfortunately, no drug has yet been found to treat cardiac toxicity or reduce the side effects caused by cisplatin. How...

Hoori Heidari Kahkesh, Negin Amini, Mohammad Badavi et al. · 0 citations
Open access Oct 2026

Hepatoprotective Effects of Dulaglutide against Methotrexate-Induced Liver Injury in Rats

Background and Objectives: The cellular antioxidant defense system is disrupted, which results in hepatotoxicity. When the antioxidant defence system is weakened, hepatocyte oxidative damage results from an increase in reactive oxygen radicals. The chemotherapeutic and immunosuppressive drug methotrexate (MTX) is often...

Omar W. Maher · 0 citations
Sep 2026

Losartan inhibits methotrexate-induced testicular damage via anti-inflammatory and anti-apoptotic effects.

It is demonstrated that AT1R inhibition using Losartan successfully mitigates MTX-induced testicular damage by addressing this upstream mechanistic pathway and Losartan has been identified as a viable treatment strategy for preserving male reproductive function following cytotoxic therapy.

Somayeh Mohammadi Panah, M. Khezri, Hojat Ghasemnejad-Berenji et al. · 0 citations

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