Urtica dioica L. Alleviates Bisphenol A-Induced Testicular Toxicity in Rats via Modulation of Oxidative Stress, Inflammation, and Apoptosis
TL;DR
UD treatment significantly reduced the adverse effects of BPA on the male reproductive system through antioxidant, anti-inflammatory, and antiapoptotic mechanisms, suggesting that UD could be considered a potential pharmacological agent in the treatment of infertility caused by BPA exposure.
Abstract
Simple Summary Exposure to food contaminants is considered one of the significant environmental risk factors that play a role in the etiology of male infertility. Bisphenol A (BPA), which is widely found in the composition of plastic products, holds a significant place among foodborne contaminants. Plants with high antioxidant capacity are frequently used for their protective effects against the toxic effects caused by BPA, which can act as an endocrine-disrupting chemical. The aim of this study was to evaluate the protective and ameliorative effects of Urtica dioica L. (UD) against BPA-induced testicular dysfunction. The findings indicate that UD treatment significantly reduced the adverse effects of BPA on the male reproductive system through antioxidant, anti-inflammatory, and antiapoptotic mechanisms. These findings suggest that UD could be considered a potential pharmacological agent in the treatment of infertility caused by BPA exposure.