TL;DR
Gastrodin may have a protective activity against CP cardiotoxicity, primarily by restoring redox balance/energy status, suppressing inflammation and apoptosis, and modulating p62–Keap1–Nrf2 related gene expression.
VIN attenuated changes in the AMPK/SIRT1 and PI3K/Akt axes, MAPK, TLR4/NF-κB p65 signaling, as well as NLRP3-related signaling in a dose-responsive manner, and its cardioprotective effects were accompanied by improved redox balance, increased AMPK/SIRT1 and PI3K/Akt expression, reduced phosphorylated MAPK abundance, an...
Doxorubicin (DOX)-induced cardiotoxicity (DIC) is a major limitation to the clinical use of DOX, highlighting the need for effective cardioprotective strategies. Although acteoside (ACT), a natural compound with antioxidant properties, has shown potential cardioprotective effects, its role in DIC, particularly in the r...
It is demonstrated that radiation-synthesized gallotannin hydrogel (GTH) exerts nephroprotective effects against ATO-induced nephrotoxicity, driven by antioxidant, anti-inflammatory, and anti-apoptotic mechanisms mediated via modulation of the miR-223/TXNIP axis.
BACKGROUND Chlorfenapyr (CFP) is a pesticide that induces nephrotoxicity through oxidative stress, mitochondrial dysfunction, inflammation, and apoptosis. Casein nanoparticles may enhance the therapeutic efficacy of chrysin (CY). OBJECTIVE This study evaluated the protective effects of free CY and chrysin-loaded case...
Morin (MOR) treatment significantly ameliorated VCM-induced renal injury by reducing oxidative injury, restoring endogenous defense systems, attenuating inflammatory responses, suppressing apoptosis, and markedly improving histopathological lesions.
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