This work proposes the “Silent Resistome Activation Model,” where resistance genes become functional only with support from identified accessory genes and coordinated interactions at both the genomic and network levels.
This study delineates the genomic landscape of C. auris Clade I, highlighting how the consolidation of multiple resistance and virulence markers contributes to its clinical success.
Ayhan Tosunoglu, Ozleyis Konyali, Mehmet Demirci· İstanbul Kuzey Klinikleri· 0 citations
Observed genomic differences align with adaptation under antimicrobial selection, though confirmation requires larger collections, and phenotypic profiling with whole-genome sequencing is integrated to examine resistance architecture in clinical isolates from eastern India.
S. Routray, T. Swarnkar, E. Subudhi et al.· International Microbiology· 0 citations
The findings indicate that Pseudomonas aeruginosa utilizes dynamic transcriptional regulation rather than genetic alteration to evade antibiotic pressure, representing a distinct evolutionary strategy for survival under antimicrobial stress.
Wei-Jie Feng, Jia Hou, Gang Li et al.· mSystems· 0 citations
Colistin (CST) is a critical last-line antibiotic for treating multidrug-resistant Pseudomonas aeruginosa infections, especially in chronic respiratory disease. Despite its clinical importance, the P. aeruginosa CST resistome remains incompletely characterised, with most studies focusing on the PAO1 prototypic strain....
Kellie R. Strickland, Miriana L. Littlejohn, Erin P. Price et al.· bioRxiv· 0 citations
Background: Enterobacter hormaechei, a significant opportunistic pathogen, is associated with antimicrobial resistance including Urinary Tract Infections (UTIs). Limited genomic information is available from Iraqi clinical isolates of E. hormaechei. This research involved an investigation of the antimicrobial resistanc...
Sahar Salim Petrus Al-Nakkar, Amera Ali Ahmed, Enas Abdul Munieem Al-Layla et al.· Journal of Pioneering Medica...· 0 citations
This study established a standardized, scalable framework for multinational antimicrobial resistance analysis to address a major gap in current surveillance, namely, fragmented monitoring of individual pathogens, and observed extensive co-occurrence of resistance fingerprint patterns among five major nosocomial pathoge...
Yen-Yi Liu, Li-Wen Huang, Mei-Fang Su et al.· Microbiology spectrum· 0 citations
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