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Cryo-EM reveals the central steps of mitochondrial complex III assembly and the cooperative assembly of supercomplex CIII2CIV

Ahad Ali Kazmi Andrea Gottinger Marine S. Huhardeaux Andrea Stärk B. Santiago-Schübel Emma J. Fenech I. Vercellino
Sep 2026 · bioRxiv · 0 citations · 45 references
Biology

TL;DR

A generalizable model for the maturation of the complex is proposed, alongside a model for supercomplex formation that supports the cooperative assembly model, and the central role of cryo-EM is showcased in the study of assembly mechanism of protein complexes.

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