Ameliorative Role of fenugreek Oil Against Lead Acetate Trihydrate-Induced Hepatic, Renal and Testicular Injury in Wistar Albino Rats: Insights into Bcl-2 Expression and sodium/potassium balance.

Protective effect of Panax ginseng on AlCl₃-induced liver, kidney, and testis toxicity in male albino rats: biochemical, histopathological, and molecular study

Aluminum chloride (AlCl₃) is a ubiquitous environmental toxicant that induces multi-organ toxicity, primarily via oxidative stress and inflammatory mechanism cascades. Panax ginseng, renowned for its pharmacologically active ginsenosides, exhibited potent antioxidant and anti-inflammatory activities. Accordingly, this...

Deciphering the protective roles of milk thistle extract against lead-induced hepato-renal dysfunction, immunosuppression, and histopathological alterations in common carp (Cyprinus carpio L)

Background: Lead (Pb) is a heavy metal that impairs organ function and immune competence in teleost fish. Aim: This study explored the protective effect of dietary milk thistle extract (Silybum marianum; MT) as a natural feed additive against sub-lethal lead acetate-induced toxicity in common carp (Cyprinus carpio...

Ferula assa-foetida Ameliorates Lead Acetate-induced Splenotoxicity and Hematological Disturbances in Rats via Enhancement of Antioxidant Defense and Suppression of Inflammatory Cytokines.

INTRODUCTION Lead poisoning poses a significant global health challenge, impairing immune function and inducing oxidative stress and inflammation, particularly in the spleen. Ferula assa-foetida, a traditional medicinal plant, exhibits antioxidant and anti-inflammatory properties, but its protective effects against lea...

The Efficacy of Ginkgo Biloba and Fenugreek as Hepatoprotective Agents Against Carbon Tetrachloride-induced Liver Injury in Male Rats

Ginkgo biloba and fenugreek extracts exhibited significant hepatoprotective and antioxidant effects against CCl₄-induced liver injury and may represent a promising natural therapeutic strategy for preventing hepatic damage.

Hepatotoxic effect of cadmium chloride and the ameliorating role of Curcumin in rats: histological, biochemical, immunohistochemical study and targeting NF-ĸB/p53/Bcl-2 pathway

Cadmium is a dangerous environmental contaminant that injures multiple organs, including the liver. Curcumin is a powerful anti-tumoral, anti-inflammatory, anti-carcinogenic, and hepatoprotective substance. The purpose of this study was to analyze the influence of Cadmium Chloride on rat livers (histopathological, immu...

Comparative Pre- and Post- Treatment Effects of Aqueous Zingiber Officinale Rhizome Extract on Cadmium-induced Renal Dysfunction in Wistar Rats: Insights into NF-kB, NrF2 and Caspase-3 pathways