Multi‐Omics Integration Identifies a Five‐Gene Metabolic Signature With Experimental Validation in Clear Cell Renal Cell Carcinoma

Abstract

Clear cell renal cell carcinoma (ccRCC) is hallmarked by profound metabolic reprogramming; however, its intricate crosstalk with the tumor immune microenvironment (TIME) and its clinical ramifications remain inadequately elucidated. This study aims to systematically decipher the metabolic‐immune interplay in ccRCC through multi‐omics integration, with the goal of identifying robust prognostic biomarkers and actionable therapeutic vulnerabilities.