Highlights • Single-cell analysis maps lactylation activity across the LUAD ecosystem.• Lactylation-high states show remodeled cell-cell communication networks.• A machine learning-derived LRPS predicts prognosis across cohorts.• Low LRPS is associated with greater immunotherapy benefit.• KRT7 promotes malignant LUAD p...
Meng Wang, Han Zhang, Qiu-Qiao Mu et al.· Translational Oncology· 1 citation
Heterogeneity in cancer‐associated fibroblast (CAF) infiltration within the tumor microenvironment is closely associated with gastric cancer progression and immune evasion; however, precise CAF‐related diagnostic markers and actionable therapeutic targets remain scarce.
Si-Hui Hou, Meng-Zhu Sang, Yan Wang et al.· Journal of Gastroenterology...· 0 citations
Highlights • Genetically proxied RAF1 and MAPK8 expression was associated with pancreatic cancer risk.• A circulating CD4+ Treg-related phenotype showed a possible partial indirect contribution.• PheWAS detected no broad genetic pleiotropic signals at the prespecified threshold.• The findings support further study of R...
Feng-Chang Lin, Wen-Wen Tu, Rong-Gui Lin et al.· Translational Oncology· 0 citations
This study aims to systematically decipher the metabolic‐immune interplay in ccRCC through multi‐omics integration, with the goal of identifying robust prognostic biomarkers and actionable therapeutic vulnerabilities.
Yi Peng, S. Qin, Xi-Wen Li et al.· Cancer Reports· 0 citations
Highlights • Constructed a two-gene (ITM2A/TCL1A) prognostic model linking adaptive immunity and radiosensitivity in cervical cancer.• Identified ITM2A and TCL1A as radiosensitizers; their downregulation promotes radioresistance.• Risk groups differ in immune infiltration, chemokine/TCR signaling, and immunotherapy res...
