gene editing

Bigger than CRISPR? A guide to the latest genome editors

A computer generated molecular structure of the CRISPR-Cas9 gene editing complex is shown, showing the guide RNA is blue, and the double-strand of the DNA is green.

Molecular design and mechanistic understanding of lipo-xenopeptide carriers for nucleic acid delivery

Initially, viral vectors represent the most efficient systems in terms of nucleic acid delivery due to their inherent evolutionary adaption for cellular entry and genomic delivery (17,18).Nonetheless, increasing interest has resulted in the development of synthetic, non-viral delivery systems as more modulable and adap...

A Comprehensive Review on Stem Cell Therapy and CRISPR/Cas Technology in the Treatment of Thalassemia

A variety of research is synthesized, examining the therapeutic potential of stem cell therapy and CRISPR/Cas technology in the treatment of thalassemia, highlighting the use of stem cell therapy and CRISPR/Cas gene editing technology as alternative treatment options.

CanProTarget

A residue-resolved prioritization platform for covalent cancer drug discovery. CanProTarget integrates cancer gene dependencies, small-molecule covalent ligand engagement measured by chemoproteomics, and base-editing evidence for individual cysteines, keeping each layer at the resolution it is measured at.

FigureLab: a browser-based tool for assembling publication-quality scientific figures

FigureLab is a single-file, browser-based application for assembling publication-quality scientific figures from image data (microscopy, western blots, histology, gels, and clinical or specimen photographs). It runs entirely client-side with no installation, server, or internet connection required, so no image data eve...

🌱 REGENERATION, REPROGRAMMING & REJUVENATION ENGINEERING AT THE LIMIT Stem Cells, Senescence, Tissue Regeneration, Epigenetic Reset, Gene Engineering, and the Emerging Science of Rejuvenation Control

🌱 REGENERATION, REPROGRAMMING & REJUVENATION ENGINEERING AT THE LIMIT Stem Cells, Senescence, Tissue Regeneration, Epigenetic Reset, Gene Engineering, and the Emerging Science of Rejuvenation Control How far can rejuvenation proceed without destroying identity? This flagship research volume explores one of the most di...

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

This review provides a structured synthesis that spans from the biological basis of mitochondrial function and transfer to the broad applications of nanomaterials in mitochondria‐targeted therapies, with a dedicated analysis of their roles in mitochondrial targeting, functional modulation, and gene editing.

🌱 REGENERATION, REPROGRAMMING & REJUVENATION ENGINEERING AT THE LIMIT Stem Cells, Senescence, Tissue Regeneration, Epigenetic Reset, Gene Engineering, and the Emerging Science of Rejuvenation Control

🌱 REGENERATION, REPROGRAMMING & REJUVENATION ENGINEERING AT THE LIMIT Stem Cells, Senescence, Tissue Regeneration, Epigenetic Reset, Gene Engineering, and the Emerging Science of Rejuvenation Control How far can rejuvenation proceed without destroying identity? This flagship research volume explores one of the most di...

Clinical Translation of Engineered Cell and Gene Therapies for HIV Cure: A Systematic Review and Target-Product-Profile Gap Analysis of Human Interventional Studies

This systematic review evaluates the clinical translation of engineered cell and gene therapies developed for HIV cure, sustained remission, or durable antiretroviral therapy (ART)-free control. The review focuses on human interventional studies evaluating genetically engineered therapeutic products, including gene-edi...

Promoter-Targeted CRISPR Correction of PMP22 Gene Dosage Restores Schwann Cell Homeostasis in Charcot-Marie-Tooth Disease Type 1A.

Collectively, patient-anchored, promoter-targeted genome editing can potentially correct pathogenic PMP22 dosage while preserving basal expression, establishing a translational iPSC-based framework for treating dosage-sensitive demyelinating neuropathies such as CMT1A.

Precision reactivation of fetal hemoglobin: expanding the gene-editing landscape for β-thalassemia

CRISPR-Cas9 Genome Editing in Mesorhizobium ciceri Through nodC Disruption for Chickpea Symbiosis Studies.

A streamlined genome-editing strategy using a broad-host-range Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-associated protein 9 (Cas9) system adapted for M. ciceri is described, providing an efficient and reproducible framework for precise gene disruption and functional genomics studies in Mesorh...