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1,701 papers
This review systematically synthesizes the liver's multifaceted roles in teleost salinity adaptation, including glucolipid metabolic reprogramming, osmosensory signaling, cytoskeleal remodeling, and hormonal coordination.
This review examines the historical development of CRISPR technology from its initial discovery as a bacterial immune mechanism to its transformation into a revolutionary genome editing tool. The narrative traces the key scientific milestones that led to the adaptation of CRISPR-Cas9 as a precise molecular scissor capa...
# Data and code for "Causal screening of the plasma proteome and skin transcriptome in keloid: six candidate loci and the limits of Mendelian randomisation for target nomination" Version v1.0. This archive accompanies the manuscript above (Li Zhifeng, Li Jingyu; Zhejiang Provincial People's Hospital). It contains the a...
It is argued that improvements in editing efficiency alone will be insufficient; clinical success will require the simultaneous achievement of tumor‐selective delivery, genomic integrity, and acceptable long‐term safety, and the continued development of novel approaches should be promoted to realize the full potential...
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The current therapeutic landscape is synthesized, pathway-targeted disease modification from etiology-directed genetic strategies are explicitly distinguished, and key translational barriers for gene-based approaches are highlighted, including target-tissue delivery to the growth-plate, dose control and durability acro...
Bread wheat (Triticum aestivum L.) increasingly encounters combinations of abiotic stresses that interact in time and whose effects are not predictable from single-stress responses. We define yield-stable resilience as the capacity to maintain grain yield under compound climate extremes without a significant penalty in...
How biotechnological innovations connect with aggregate productivity growth in agriculture amid a changing climate remains a critical question. This paper examines the aggregate effects of genetically modified and gene-edited organisms (GMOs) using a novel dataset of harmonized agricultural production accounts for 15 O...
This article presents a narrative review of CRISPR and the Editing of the Genome in the context of Biology. The literature on this topic has expanded substantially over recent decades, yet it remains fragmented across subfields, methods, and national research traditions. Drawing on an interpretive synthesis of represen...
It is argued that future progress will depend on cell-resolved longitudinal multi-omics, causal epigenome editing, human tissue validation, and biomarker studies designed around prespecified clinical utility rather than statistical association alone.
Cancer remains a major cause of global mortality, while late-stage diagnosis and therapeutic resistance highlight the need for individualized strategies. Nanotheranostics has emerged as a promising paradigm by integrating cancer diagnosis and treatment within multifunctional nanosystems. However, most current approache...
In vitro perturbation is used to decipher the early transcriptional response programs in patient-derived 2D and 3D cell models of PDAC to KRAS inhibition and identify a robust RNA-based signature with potential utility for pharmacodynamic monitoring and the study of adaptive resistance.
This review summarizes current knowledge of CGMMV infection processes, host susceptibility factors, antiviral defense pathways, resistance resources, and resistance-associated loci in cucumber and related cucurbits and outlines an integrated framework for translating molecular findings into durable CGMMV-resistant cucu...
Genie 4: our new world model unlocking unprecedented realism in real-time simulation.
Generative AI
General Science
A Blog post by NVIDIA on Hugging Face
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
General Science
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