《Nanomedicine & Biointerfaces at the Limit: Precision Delivery, Diagnostics, Sequencing, Regeneration, and Safe Human Interfaces》 is a flagship-scale research volume exploring what happens when nanoscale engineering begins to interact directly with living systems. The central question is not simply: Can nanoparticles...
The classical rice framework that underpins biofortification, including Strategy II-type uptake, nicotianamine and deoxymugineic acid chemistry, long-distance transport, grain loading, ferritin buffering, and vacuolar sequestration are summarized.
An enhanced CgCas12n system (eCgCas12n) is established that enables efficient mammalian genome editing and provides an efficient genome- and base-editing platform for functional genetic studies.
Bo-Wen Hou, Xin-Yi Liu, Jia-Wen Fan et al.· Molecular Systems Biology· 0 citations
Recent advances in programmable large-DNA writing in the human genome are reviewed across four mechanistic categories: recombinase-, prime editing-, transposase-, and retrotransposon-mediated technologies.
Joon A. Shin, Matthew Hoffman, Xin D. Gao· Current Opinion in Chemical...· 0 citations
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Ultrasound-CRISPR technologies are elaborates potential as a powerful tool that enables targeted, and image-guided genetic interventions, capable of advancing the outcomes of gene therapy as a widespread clinical practice.
Sara Maham, B. Sridharan, J. Park et al.· Advanced Healthcare Material...· 0 citations
Persistent infection with high-risk human papillomaviruses (hrHPVs) is a primary driver of cervical carcinogenesis, with the viral oncogenes E6 and E7 playing pivotal roles. Conventional nuclease-based gene-editing strategies are limited by genome-wide off-target effects and genomic perturbations associated with double...
Yue Kang, Yi-Fan Wu, Bing-Ting Bao et al.· Molecular Therapy· 0 citations
A comprehensive genome-wide analysis identified 19 serine protease-like DEG family proteins in potato, revealing their structural diversity, domain architecture, and regulatory potential and highlighting the functional versatility of DEG proteases in potato development and stress adaptation.
Abhilash Reddy Gangula, Payal Mavadiya, Krishnakant D. Tandel et al.· Potato Research· 0 citations
This work presents a variant-agnostic approach to rescue haploinsufficiency by mapping and rationally redesigning the MYBPC3 promoter and identifies synergistic sequence edits that drive robust increases in MYBPC3 expression.
Aaron Renberg, S. Coppersmith, Owen Merritt et al.· bioRxiv· 0 citations
It is demonstrated that a synthetic circular intermediate, or “starmid”, is sufficient for recombinase-dependent integration into the host genome and that circularisation enhances expression of the starship-encoded tyrosine recombinase through juxtaposition of 3′ and 5′ terminal sequences.
Allira Baericke, Vanta J. Jameson, Andrew S. Urquhart· bioRxiv· 0 citations
This review presents the stem cell technologies applied in tissue engineering, regenerative medicine, or organ transplantation. It describes how certain types of stem cells are different in terms of their characteristics, the methods of their culture isolation, gene editing, and three-dimensional organoid construction....
Charan Sai Lanka· International Journal of Sci...· 0 citations
Cancer remains a major cause of global mortality, while late-stage diagnosis and therapeutic resistance highlight the need for individualized strategies. Nanotheranostics has emerged as a promising paradigm by integrating cancer diagnosis and treatment within multifunctional nanosystems. However, most current approache...
Lida Dastanpour, Mohammad Aref Bagherzadeh, Sanaz Rezaeian et al.· Figshare· 0 citations
This review examines the historical development of CRISPR technology from its initial discovery as a bacterial immune mechanism to its transformation into a revolutionary genome editing tool. The narrative traces the key scientific milestones that led to the adaptation of CRISPR-Cas9 as a precise molecular scissor capa...
Zen Revista, 10 BIOLOGY· Zenodo (CERN European Organi...· 0 citations
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
