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1,701 papers
UnZipro is presented, an efficient, scalable, and generalizable framework for zero-shot, in silico protein evolution, that integrates a compact, pre-trained inverse folding model with meta-learning to derive family-specific fitness landscapes.
This study provides high-quality mitogenome assemblies for P. calleryana and P. betulifolia, revealing coexisting structural variations and highly conserved sequences, and thereby offers a significant genetic resource for the Rosaceae family that will facilitate further investigations into the molecular diversity and g...
It is demonstrated that co-inactivation of HSD17B11 followed by PAC selection can be used to rapidly identify efficient guide RNAs targeting a gene of interest and to readily isolate clones inactivated for one or multiple genes.
A Python script that draws tRNA cloverleaf secondary-structure diagrams from tRNAscan-SE output. Every structure is drawn on the same fixed template: acceptor stem up, D-arm left, anticodon arm down and T-arm right, with the anticodon highlighted and a 3′-CCA appended. Base pairs, stem and loop lengths, and anticodon p...
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Although recent studies suggest the dysbiosis of gut microbiome in multiple system atrophy, as a contributor to dysfunctional intestinal barrier, new methods, including fecal RT-QuIC, smell testing, microbiota replacement, and gene-editing therapies, offer more promising evidence for diagnosis and disease-modifying the...
A Python script that draws tRNA cloverleaf secondary-structure diagrams from tRNAscan-SE output. Every structure is drawn on the same fixed template: acceptor stem up, D-arm left, anticodon arm down and T-arm right, with the anticodon highlighted and a 3′-CCA appended. Base pairs, stem and loop lengths, and anticodon p...
This review synthesizes contemporary breakthroughs in HSCT biology, technology, and clinical application, critically examines unresolved barriers, and highlights future directions, including Artificial Intelligence (AI)-driven predictive analytics, universal donor platforms, and equitable global access strategies.
The El-Rakhawi Creed presents a revolutionary philosophical-scientific exploration of the human genome as the fundamental text of existence. This work transcends conventional molecular biology to reveal the genome as both a sacred autobiography of our species and a dynamic interface between genetic inheritance and envi...
This dataset contains raw NGS reads (NGS_data folder), fluorescence microscopy photos (Fig7B Microscopy Originals.lif) and flow cytometry data (@Fig6 FACS original data.zip) derived from transgenic maize (Zea mays L.) in vitro tissues exposed to chromatin modifiers. They are presented in research article ˝Variable Alte...
Monogenic genetic disorders are caused primarily by pathogenic variants affecting a single gene and represent an important group of inherited diseases. Although many of these conditions are individually rare, their cumulative impact on global health is substantial. Conventional treatment strategies are often directed t...
Gene therapy and genome editing technologies have advanced significantly in recent decades and have shown great potential for treating inherited and acquired diseases. CRISPR-Cas is one of several genome editing tools currently being studied and has gained widespread popularity due to its ease of use, versatility, and...
Surprisingly, id1- te1- plants exhibited a synergistic floral delay, producing ∼90 leaves before inflorescence production, raising the hypothesis that meristem leaf primordia cessation underpins maize flowering.
Genie 4: our new world model unlocking unprecedented realism in real-time simulation.
Generative AI
General Science
A Blog post by NVIDIA on Hugging Face
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
General Science
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