This study describes the development and application of a wheat-compatible prime-editing system to introduce the Lr67-associated TaSTP13(G144R) resistance allele into the A, B, and D TaSTP13 homoeologs of hexaploid wheat. Edited lines were generated and characterized for editing efficiency, followed by evaluation of le...
Rafael E. Venado, Joshua Waites, Easter D. Syombua et al.· Figshare· 0 citations
Micronutrient deficiencies, particularly of iron (Fe) and zinc (Zn), are major global health concerns for humans, especially in populations that rely heavily on cereal-based diets. Rice grains, one of the world’s most consumed staple crops, have low concentrations of bioavailable Fe and Zn, especially in the endosperm...
P. K. Menguer, Lucas Adamy Lenhardt, Marcos Bönes et al.· Frontiers in Plant Science· 0 citations
Common buckwheat (Fagopyrum esculentum) is a climate-resilient pseudocereal; however, its global adoption is constrained by the heteromorphic self-incompatibility associated with distyly. While the S-locus early flowering 3 (FeS-ELF3) gene has been identified as a key regulator of self-compatibility, a stable genetic t...
Artur Piński, Magdalena Zaranek, Joanna Lusinska et al.· Frontiers in Plant Science· 0 citations
Origanum vulgare is a perennial herb known for its antimicrobial, antioxidant, and anti-inflammatory properties, valued in both traditional medicine and modern phytopharmacology. Despite substantial research on its chemical and pharmacological properties, genomic studies have been limited. In this study, we present the...
Curated dataset and analysis code for a deduplicated census of the mobilized colistin resistance (mcr) gene family in the August 2026 NCBI snapshot (AMRFinderPlus Reference Gene Catalog 2026-08-07.1). Contents. Four archives: (1) core curated datasets (1,298 → 1,106 records, 454 unique proteins, 284-protein QC-triage c...
Shilei Dong· Zenodo (CERN European Organi...· 0 citations
Curated dataset and analysis code for a deduplicated census of the mobilized colistin resistance (mcr) gene family in the August 2026 NCBI snapshot (AMRFinderPlus Reference Gene Catalog 2026-08-07.1). Contents. Four archives: (1) core curated datasets (1,298 → 1,106 records, 454 unique proteins, 284-protein QC-triage c...
Shilei Dong· Zenodo (CERN European Organi...· 0 citations
This comprehensive foundational module analyzes the systems architecture and developmental mechanics of emerging technologies across the modern STEM curriculum. Developed by Prep4Uni.Online, this resource serves as an analytical bridge connecting laboratory-stage scientific discovery to scalable industrial engineering...
Prep4Uni.Online· Zenodo (CERN European Organi...· 0 citations
This archive supports the manuscript "Mitoxyperilysis-consistent L4 de-protection in human sepsis-associated ARDS blood: a compartment- and etiology-bounded transcriptomic boundary map" (submission target: Critical Care, BMC; manuscript version v2.34, September 2026). Contents: (1) complete analysis code (R 4.6.1 / Pyt...
linhuangwei, Yuanshui Liu· Zenodo (CERN European Organi...· 0 citations
CRISPR–Cas9 genome editing has transformed biomedical research by enabling precise and efficient genetic modification. Among its applications, gene knockout using ribonucleoprotein (RNP) complexes provides a non-viral strategy for introducing loss-of-function mutations. Here, we present an optimized CRISPR–Cas9 RNP-bas...
Andrea Šarac, Klemen Kunej, Kristina Manzoni et al.· Scientific Reports· 0 citations
CD4+ T cells orchestrate adaptive immunity and strategies that enable their genetic reprogramming hold promise for treating cancer, immune dysregulation and infectious diseases such as HIV. However, current T cell engineering approaches rely heavily on ex vivo manipulation, which is labor-intensive, costly, and can alt...
Maaike De Cock, Elianne Burg, Sarah Gerlo et al.· Advanced Healthcare Material...· 0 citations
Abstract Cancer, neurologic diseases, cardiovascular disease, metabolic disorders, immune disorders, and some inherited diseases are examples of epigenetic diseases. Traditional epigenetic drugs are non-specific and may be toxic at higher concentrations, may be unstable in transcription, and may have off-target effects...
Preprint — not yet peer reviewed. This pilot computational study evaluates a TCGA gene-expression cancer classifier across six cancer types: BRCA, COAD, READ, LUAD, LUSC, and OV. The analysis focuses on patient-grouped cross-validation, training-only preprocessing, class-specific performance, tissue-source-site confoun...
Hitesh Sharma· Zenodo (CERN European Organi...· 0 citations
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
