A novel theoretical concept in bio-hybrid robotics and tissue engineering: a macroscopic biological muscle actuator engineered from the stem cells of the Oriental Hornet (Vespa orientalis). The system utilizes CRISPR-Cas9 genome editing to multiply the Alcohol Dehydrogenase (NADP+) gene for absolute alcohol immunity, c...
Lucian-Razvan Popovici· Zenodo (CERN European Organi...· 0 citations
A novel theoretical concept in bio-hybrid robotics and tissue engineering: a macroscopic biological muscle actuator engineered from the stem cells of the Oriental Hornet (Vespa orientalis). The system utilizes CRISPR-Cas9 genome editing to multiply the Alcohol Dehydrogenase (NADP+) gene for absolute alcohol immunity, c...
Lucian-Razvan Popovici· Zenodo (CERN European Organi...· 0 citations
This comprehensive foundational module analyzes the systems architecture and developmental mechanics of emerging technologies across the modern STEM curriculum. Developed by Prep4Uni.Online, this resource serves as an analytical bridge connecting laboratory-stage scientific discovery to scalable industrial engineering...
Prep4Uni.Online· Zenodo (CERN European Organi...· 0 citations
A novel theoretical concept in bio-hybrid robotics and tissue engineering: a macroscopic biological muscle actuator engineered from the stem cells of the Oriental Hornet (Vespa orientalis). The system utilizes CRISPR-Cas9 genome editing to multiply the Alcohol Dehydrogenase (NADP+) gene for absolute alcohol immunity, c...
Lucian-Razvan Popovici· Zenodo (CERN European Organi...· 0 citations
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1. What is already done, and what this document covers I state this first, because the value of a preregistration written after related work depends on being exact about what was already seen. Three analyses are already complete and are exploratory. None of them was preregistered, and none of them is covered by this do...
Abstract Cancer, neurologic diseases, cardiovascular disease, metabolic disorders, immune disorders, and some inherited diseases are examples of epigenetic diseases. Traditional epigenetic drugs are non-specific and may be toxic at higher concentrations, may be unstable in transcription, and may have off-target effects...
Preprint — not yet peer reviewed. This pilot computational study evaluates a TCGA gene-expression cancer classifier across six cancer types: BRCA, COAD, READ, LUAD, LUSC, and OV. The analysis focuses on patient-grouped cross-validation, training-only preprocessing, class-specific performance, tissue-source-site confoun...
Hitesh Sharma· Zenodo (CERN European Organi...· 0 citations
How advances in large DNA assembly, synthetic biology, and genome-wide validation are making chromosome-scale genome engineering an increasingly tractable experimental framework for understanding, building, and repairing genomes is discussed, while outlining the analytical requirements and current technical barriers th...
Miriam Saponaro, Pierre Murat, Francesca Agostini et al.· Trends in Genetics· 0 citations
A complete, gap-free genome of Medicago lupulina, a tough, high-protein forage legume, and a gene-editing tool for this species, which was used to alter its leaf shape, provide key resources for improving alfalfa and breeding better forage crops for high-altitude environments.
Qing Yuan, Cheng Li, Guang-Yan Wang et al.· Journal of Integrative Plant...· 0 citations
Overall, CRISPR-based technologies show considerable potential to support precision oncology in prostate cancer by enabling molecularly informed therapeutic strategies and addressing treatment resistance, although challenges related to delivery, off-target effects, tumor heterogeneity, immunogenicity, and clinical tran...
Vaibhavkumar Patel, Pratichi Singh, S. Dutta et al.· Critical reviews in oncology...· 0 citations
This study establishes the feasibility of dCasRx-mediated programmable RNA base editing in plant cells and lays a foundation for further optimization of editing efficiency and stable in planta editing performance.
Xue-Ming Ruan, Zi-Yan Zhang, Xiang-Yu Xiong et al.· Biochemical and Biophysical...· 0 citations
The adaption of the continuous directed evolution (CDE) along with base editor (BE) gene editing strategy to discover TEM-1 mutants is reported here and highlights the application of gene editing methods to provide insight into the molecular basis of antibiotic resistance.
Hong Wang, Jia-Mei Wang, Ding-Jue Zhang et al.· Biotechnology Letters· 0 citations
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
