Characterization and Antibacterial Activity of a Low-Molecular-Weight Bacteriocin-like Inhibitory Substance S-2 Produced by Leuconostoc falkenbergense SBL-85-2 Against Aeromonas hydrophila
Experiments confirmed that this substance is heat-stable, non-toxic, and exerts antibacterial activity through disruption of the outer membrane, which provides a novel strategy for controlling A. hydrophila in aquaculture.
Abstract
Simple Summary This study aimed to characterize BLIS S-2, a bacteriocin-like inhibitory substance produced by lactic acid bacteria, and evaluate its potential against the aquatic pathogen Aeromonas hydrophila. Experiments confirmed that this substance is heat-stable, non-toxic, and exerts antibacterial activity through disruption of the outer membrane. Collectively, these findings provide a novel strategy for controlling A. hydrophila in aquaculture and offer a promising direction for reducing antibiotic dependence and developing safe, effective alternatives.
Findings indicate that BLIS WYQ-2cin possesses potential as a natural antibiotic alternative for the prevention and control of porcine bacterial diarrhea.
PAM3-2 is a proteinaceous bacteriocin-like antibacterial substance produced by marine-derived A. pittii with high physicochemical stability, and exhibits broad-spectrum antibacterial activity, particularly against S. Paratyphi B, and its antibacterial effect is associated with disruption of membrane integrity.
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