Aug 2026· Clinical and Translational Oncology· 0 citations· 50 references
Medicine
TL;DR
Collectively, the advances are an indication of a transition to the personalized, mechanism-driven treatment strategies that would prolong the survivability of patients with advanced thyroid cancer, conquer resistance, and reduce systemic toxicity.
Progress in the understanding of ATC biology is highlighted, with a focus on driver genetic alterations, metabolic plasticity and microenvironmental interactions that underpin its exceptional aggressiveness, to provide a rationale for the design of multimodal therapeutic strategies urgently needed to improve outcomes for patients with ATC.
Targeted therapy demonstrates temporary efficacy in anaplastic thyroid carcinoma; however, the development of resistance and the aggressive nature of the disease significantly limit long-term treatment outcomes.
N. Sloneva, I. Turkpenova, D. Dubchev· Eurasian Journal of Oncology...· 0 citations
This review underscores the transformative potential of molecular profiling and FGFR-targeted therapies in the evolving management of bladder cancer, with special attention given to the fibroblast growth factor receptor (FGFR) signaling pathway.
Nandita Yadav, Nihar Ranjan Sarmah, Ketan J. Purohit et al.· Current Pharmacogenomics and...· 0 citations
The present review systematically reviewed recent epidemiological trends in thyroid cancer and provided an in-depth exploration of the molecular regulatory mechanisms of key signaling pathways, including MAPK, PI3K/AKT, Janus kinase/STAT, WNT/β-catenin and NF-κB, along with their roles in the pathogenesis and progression of thyroid cancer.
Jian Wang, Zhi Liu, Qing Zhang et al.· International Journal of Onc...· 0 citations
Key oncogenic signaling pathways, including PI3K/AKT/mTOR and RAS/RAF/MEK/ERK, were discussed in the context of therapeutic targeting and precision medicine and emerging strategies, particularly immunotherapy and combination approaches were addressed.
Xinyu Li, Jie Liu, Fang-Fang Huang et al.· Oncology Letters· 0 citations
An overview of the molecular mechanisms of RET alterations in thyroid cancer, targeted therapies, and emerging resistance to targeted treatment is provided.
Shujing Mao, Nan Zhou, Liyuan Huang et al.· Critical reviews in oncology...· 0 citations