This work identifies a previously unrecognized bacterial target of VgrG1-ACD: MreB, the bacterial actin homolog essential for cell shape, cell wall synthesis, and cytoskeletal organization and uncovers a dual-targeting strategy through which a single T6SS effector manipulates both mammalian actin and its bacterial homolog.
TpeX is identified as a bactericidal, colicin-like pore-forming T6SS effector whose membrane activity is controlled by a cognate immunity protein, thereby expanding the repertoire of membrane-targeting weapons used by P. aeruginosa in interbacterial competition.
Chantal Soscia, Sébastien Reig, D. Lefebvre et al.· bioRxiv· 0 citations
ABSTRACT The type IV secretion system (T4SS) acts as the central virulence determinant of Brucella, facilitating intracellular survival via the secretion of effector proteins. In this study, we combined bioinformatic prediction with translocation assays to identify seven novel VirB-dependent effectors. Functional chara...
Conditional T6SS silencing is identified as a potential adaptive strategy that promotes survival within multispecies microbial communities, particularly in environments containing bacteria with highly active or more potent T6SS machineries.
Stephan P. Ebenberger, J. Pombo, Alexander Rechberger et al.· Microorganisms· 0 citations
This work probes the structure and function of the orphan toxin-immunity pair Rhs2-SciX, demonstrates the biochemical diversity of Salmonella T6SS effectors, and highlights the conserved T6SS toxicity strategy of binding EF-Tu.
N. Cobo, S. Goyal, David E. Davidson et al.· Journal of Molecular Biology· 0 citations
Genetic analysis and structural modeling indicate that TseMt is delivered through a dedicated PAAR−VgrG−chaperone pathway, defining the structural basis, functional mechanism, and delivery pathway of the H4‐T6SS effector TseMt from a clinical P. aeruginosa isolate.
Salmonella enterica relies on type III secreted effector proteins to invade host cells and establish an intracellular replicative niche, the Salmonella-containing vacuole (SCV). Among these effectors, SopB (also known as SigD) is notable for its functional versatility, contributing to virtually every stage of infection...
Ronan C. Jensen, Gregory D. Fairn· Discover Bacteria· 0 citations
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