The crystal structures of CI4Tase are determined and the strict size-control mechanism of CI4Tase is elucidated, providing a structural foundation for engineering cycloisomaltooligosaccharide-producing enzymes with optimized transglycosylation efficiency and specificity for industrial applications.
These findings establish the structural basis of sulX-mediated sulfonamide degradation and provide a foundation for understanding sulfonamide resistance mechanisms.
Yu-Mei Hu, Wan-Huan Liu, Qi-Shan Zhang et al.· Journal of Hazardous Materia...· 0 citations
Much has been achieved in the 135-year history of cyclodextrin research and all that goes with it. Cyclodextrins are ring-shaped molecules composed of glucose residues produced by the enzymatic transformation of starch and have toroidal structures with a hydrophobic cavity and a hydrophilic surface that allow them to f...
A. Baymiev, R. Garafutdinov, A. Chemeris· ÈKOBIOTEH· 0 citations
Uridine diphosphate glycosyltransferases (UGTs) are among the key rate-limiting enzymes in the biosynthesis of salidroside. Plant-derived UGTs often exhibit poor solubility and low catalytic activity, whereas microbial UGTs typically show insufficient regioselectivity for salidroside production. In this study, we per...
Mu-Yang Li, Yi-Wei Meng, Ji-Shan Li et al.· ACS Catalysis· 0 citations
Cyclodextrin glucanotransferases (CGTases, EC 2.4.1.19) convert starch to cyclodextrins (CDs) in three major homologues (α-, β-, γ-) that are widely used in various sectors. CGTase of Paenibacillus ehimensis IB 739 is unique in providing a stable cyclodextrin ratio irrespective of the dose of the enzyme and has the rar...
E. Gilvanova, P. Milman, N. N. Usanov· ÈKOBIOTEH· 0 citations
Peptidoglycan (PG) is the key structural component of the bacterial cell wall, responsible for cellular shape and structural integrity. Postsynthetic modifications to PG enable bacteria to evade innate immunity and regulate endogenous autolysins. Among these, C-6 O-acetylation protects PG from lysozyme degradation, whi...
Dmytro Voskoboinyk, M. E. Tanner· Chemistry· 0 citations
Terpene cyclases (TCs) typically transform acyclic oligoprenyl pyrophosphates through carbocationic cyclization cascades. However, recently discovered bacterial pathways generate compact, cyclized and stereochemically defined noncanonical intermediates through methyltransferases prior to TC catalysis, raising the que...
Ke-Xin Yang, M. Groll, Jeroen S. Dickschat· Journal of the American Chem...· 0 citations
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