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#gene editing

Discovery and engineering of avian R2 retrotransposons for all-RNA-mediated targeted DNA integration in human cells.

Yang-Can Chen Yan-Ping Hu Sheng-Qiu Luo Bang-Wei Mao Na Tang Chen-Xin Wang Yu-Ze Wang Han-Yu Bai Xin-Ge Wang Chang-Xian Peng Qi-Cheng Chen Jia-Hui Xiao Yu Zou Peng Wang Rui Niu Jin Zhang Yu-Long Zhao Chen Liang Yun-Long Wang Yi-Yun Li Jun-Jie Wang Ng Shyh-Chang Tuo Wei Hao-Yi Wang Qi Zhou Wei Li
Oct 2026 · Nature Biotechnology · 0 citations · 46 references
Medicine

TL;DR

This work searched avian genomes, identified 159 avian R2 retrotransposons and characterized conserved/nonconserved sequence features in their proteins and untranslated region elements, which expands the avian R2 resource and provides additional tools for all-RNA-mediated genome editing.

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