Skip to content

Carvacrol induces apoptosis, modulates oxidative stress, and promotes G0/G1 cell cycle arrest in colorectal cancer cells.

Jul 2026 · Molecular and Cellular Biochemistry · 0 citations · 31 references
Medicine

TL;DR

It is demonstrated that carvacrol effectively inhibits CRC growth while exerting limited effects on normal colon fibroblasts, which support the further investigation of carvacrol as a potential complementary therapeutic agent for CRC.

View source

Similar papers

Open access Aug 2026

10-HDA Suppresses the Growth of Gastric Cancer Cells Through Inducing Apoptosis and G0/G1 Cell Cycle Arrest

Preliminary mechanistic insights into the effects of 10-HDA on gastric cancer cells are provided, demonstrating that 10-HDA suppresses the malignant phenotype of gastric cancer cells by coordinated activation of apoptosis and cell cycle blockade.

Lei Huang, Tianxin Lin, Shou-Fu Jiang et al. · 0 citations
Open access Aug 2026

Emodin Induces AIF-Associated Apoptosis and Suppresses Wnt/β-Catenin Signaling in Colorectal Cancer Stem-Like Cells

Collectively, emodin suppresses CRCSC characteristics in vitro by downregulating Wnt/β-catenin signaling and inducing AIF-associated caspase-independent apoptosis, highlighting its therapeutic potential against CRC.

M. Ahmadi, Hong Lae Kim, H. Jung · 0 citations
Open access Aug 2026

Narciclasine Exerts Anticancer Activity in Colorectal Cancer Cells in Association with HELLS Downregulation and DNA Damage-Associated Responses

Narciclasine is a promising natural-product-derived lead compound for further preclinical evaluation in HELLS-associated CRC vulnerabilities and is associated with HELLS downregulation, DNA damage-associated signaling, and apoptosis in CRC cells.

Yoon-Mi Lee, Su-Min Han, G. Park et al. · 0 citations
Aug 2026

Bullatine A Attenuates Proliferation in Breast Cancer Cells by Apoptosis via PI3K/AKT/mTOR Signaling Pathway in Vitro and in Silico Analysis and Pharmacological Analysis

It was revealed that BLA could reduce MCF-7 cell viability, adhesion, and migration while elevating intracellular ROS, autophagy, and apoptosis in an amount-dependent way and that BLA may be a natural anti-cancer agent to prevent BC metastasis.

Xinyuan Niu, Periyannan Velu, A. Vijayalakshmi · 0 citations
Sep 2026

Boric Acid Induces Oxidative Stress-Associated Cytotoxicity and Modulates Wnt Signaling in MALME-3M Cells.

Overall, BA exerted antiproliferative effects in MALME-3M cells accompanied by oxidative stress-associated cytotoxicity and changes in apoptosis-related markers, cell-cycle progression, migration-related features, and Wnt signaling-related markers.

Ş. Çelik, Hatice İlayhan Karahan, M. Soyöz et al. · 0 citations
Open access Sep 2026

Epigallocatechin Gallate Modulates the Cellular Response to Doxorubicin in HeLa Cervical Cancer Cells

Overall, EGCG and DOX exhibited synergistic interactions and multiple treatment-associated cellular and transcriptional responses in HeLa cells under the present in vitro conditions, which provide a basis for validation in additional cervical cancer models and at clinically relevant exposures.

Mehmet Emin Ayağ, M. Tuncer, Ş. Öztürk · 0 citations

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.