Jul 2026· Journal of Diabetes and Metabolic Disorders· Vol 25· 0 citations· 122 references
Medicine
TL;DR
The definite clinical significance of APC mutations in PTC emergence is not fully understood, and additional prospective and translational studies are required to elucidate their biological and clinical advantages in diagnosis, prognosis, targeted therapy, and individualized patient management.
The present review systematically reviewed recent epidemiological trends in thyroid cancer and provided an in-depth exploration of the molecular regulatory mechanisms of key signaling pathways, including MAPK, PI3K/AKT, Janus kinase/STAT, WNT/β-catenin and NF-κB, along with their roles in the pathogenesis and progressi...
Jian Wang, Zhi Liu, Qing Zhang et al.· International Journal of Onc...· 0 citations
OBJECTIVE
Papillary thyroid carcinoma (PTC) is a well-differentiated malignancy derived from thyroid follicular epithelial cells. This study explores the functional role and underlying mechanisms of LINC01521 in PTC, aiming to provide new strategies to improve prognostic assessment and survival rates for PTC.
METHODS...
Xiaotao Duan, Zai-Kai Lin· The Laryngoscope· 0 citations
It is found that the inflammatory molecule interleukin-1 beta (IL1β) was reduced in PTC tissues and was associated with lymph node metastasis and was associated with lymph node metastasis.
The review discusses the key genetic drivers of pancreatic carcinogenesis, including KRAS, TP53, CDKN2A, SMAD4, and BRCA1/2, and emphasizes the role of these genes as therapeutic biomarkers for the development of targeted molecular therapy.
S. Kaviya, G. Sivakumar, P. Anandhasankar· International Journal of Inn...· 0 citations
This review examines the foundational signaling mechanisms implicated in CRC, with an emphasis on the Wnt/β-catenin, GUCY2C, MAPK/ERK, p53, PI3K/AKT, and SMAD4/TGF-β pathways.
Allison S. Doermann, Adi Caspi, Andrew E. Evans et al.· Cancer Biology & Therapy· 0 citations
Together, these studies emphasize that Wnt/ b -catenin signaling is controlled at multiple regulatory levels and cellular compartments, supporting context-speci c and biomarker-guided therapeutic strategies.
S. Patergnani, D. Buchsbaum, G. Piazza et al.· Frontiers in Oncology· 0 citations
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