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hsa_circ_0008758 Activates the MDM2/FOXO3a/PGK1 Pathway Through the miR-361-3p/SPIN1 Axis to Promote the Warburg Effect of Non-Small Cell Lung Cancer

Lei Wei Fei Xu Lei Xiong Le-Le Wang Hairong Huang Kang Wang Jing Luo Yi Shen Yan-Qing Wang Feng Jiang
Jul 2026 · Tissue Engineering and Regenerative Medicine · Vol 23, pp. 867 - 879 · 0 citations · 63 references
Medicine

TL;DR

Inhibiting circ_0008758 or elevating miR-361-3p resulted in decreased proliferation, migration, invasion, and Warburg effect in NSCLC cells, while promoting cell apoptosis, and circ_0008758 was found to enhance SPIN1 expression by acting as a sponge for miR-361-3p.

DOI PubMed Semantic Scholar
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