Three commonly used types of neutralization assay were compared and strong correlations and significant differences in measured neutralization between the different assays were found, highlighting areas for more precise and harmonized terminology and particular assay elements that must be considered in efforts to harmonize neutralization assays.
E. Stadler, F. Mordant, Matthew J. Gartner et al.· Journal of Virology· 0 citations
It is found that the MIC10 proteins Mic10, Mic26, and Mic27 strongly recruit cardiolipin at conserved positive loop motifs, driving oligomerization of these subunits and resulting in the stabilization of curvature in model membranes.
C. Brown, T. Wassenaar, Z. Freyberg et al.· Science Advances· 0 citations
AgentFold is presented, a multi-agent framework that formulates folding-model development as a closed-loop search over executable code variants and improves the best lDDT by 7.5% over independent Codex proposals and outperforms a random-search control.
Mingquan Liu, Jiangyue Chen, Hanqun Cao et al.· 0 citations
This survey reviews the basic principles of LLMs and summarizes representative applications in gene and genome sequence analysis, protein structure and function prediction, and drug design, including virtual screening and personalized medicine.
Zhigang Meng, Zhi-Kai Yang, Mingming Zhu et al.· Frontiers in Genetics· 0 citations
This study demonstrates the successful production and injection of human induced pluripotent stem cell cardiomyocyte aggregates into infarcted cynomolgus monkey hearts, resulting in substantial, structured human grafts three months after cell transplantation, and uncoupling of cardiomyocyte production from transplantation is demonstrated.
I. Gruh, Andreas Martens, S. Cebotari et al.· Nature Communications· 0 citations
A genome engineering technology is used to change a single amino acid in the viruses’ main protease enzyme to match that of circulating Omicron isolates to demonstrate antiviral efficacy of approved drugs and uncover mutants with reduced drug sensitivity.
It is found that this test to judge whether a computer program predicts whether a genetic variant causes disease is easier to pass than it looks, and about half the advantage held by programs trained on clinical data disappears once the gene pattern is removed.
Saad Harrizi, I. Nait Irahal, Kabine Mostafa et al.· bioRxiv· 0 citations
Findings highlight compound D as a promising lead candidate for short-bath therapy against N. melleni and suggest that cytoskeletal disruption through β-tubulin interaction represents a plausible mechanism of action.
A generalized essential dynamics-refined ENM (edENM) is introduced for both DNA, RNA, and protein-nucleic acid complexes, parametrized against a diverse set of molecular dynamics simulations and validated using experimental ensembles from nuclear magnetic resonance, X-ray crystallography, and cryogenic electron microscopy.
Domenico Scaramozzino, Marco Cannariato, Byung Ho Lee et al.· Nucleic Acids Research· 0 citations
This research introduces a novel strategy to augment casein expression in ruminants, providing a significant theoretical foundation and technical support for the precision breeding of high-casein dairy cows and goats.
Zhenliang Zhu, Xiaoyu Mi, Wei Yu et al.· Journal of Dairy Science· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
