The results uncover an intricate interplay between active and silent epigenetic features present at the b1 locus in a mop1 background, resulting in elevated expression of B’, concluding that MOP1 is essential to maintain the B’ silent chromatin state.
FAIRE analysis on these mutants suggests that the occurrence of physical interactions appears not dependent on a particular chromatin state, and a B-I -like multi-loop structure mediates high b1 expression.
M. Louwers, R. Bader, R. van Driel et al.· 0 citations
A conserved role of CTCF is supported in preventing DNA methylation spreading and gene silencing of cell-type-specific genes along differentiation, and a similar role of CTCF on DNA methylation and gene expression in the human orthologous gene HBA2.
Gustavo Tapia-Urzúa, H. N. Núñez-Martínez, Sylvia Garza-Manero et al.· Epigenetics· 0 citations
This chapter speculates that physical in trans interactions could be involved in paramutation as well, and potential mechanisms will be discussed in light of recent data obtained for the b1 locus.
M. Louwers, M. Stam, J. Bennetzen et al.· 0 citations
This study shows that Arabidopsis thaliana colonizing the Cape Verde Islands rapidly evolved altered DNA methylation patterns through high-impact mutations affecting VIM2/4, CMT2 and FBX5, linked to alternative drought adaptation strategies.
Johan Zicola, Emmanuel Tergemina, Ahmed F. Elfarargi et al.· Nature Plants· 2 citations
This study provides the first direct evidence in a human model that transcription across the PWS-SRO is necessary but not sufficient for de novo DNA methylation, and suggests differentiation-dependent cues, potentially resembling aspects of the oocyte environment, are required.
Josephine Haake, Alexander Lederhof, Claudia Pommerenke et al.· bioRxiv· 0 citations
The results suggest an autoinhibited form of Set2 in which the catalytic domain (CD) is bound by the AID, and biophysical experiments demonstrate that the CD and AID physically interact, and that the autoinhibition mutants disrupt this interaction.
Alexandra R. Elchert, Vanda Lux, James L. Warner et al.· Nucleic Acids Research· 0 citations
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